Results 51 to 60 of about 10,941,453 (300)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Defining Digitalities I: What’s Digital about Digits?
, 2023 Modern discourses emphasizes electronic immateriality as the defining feature of digital technology. The idea that digits might be digital when punched onto cards, or even written on a piece of pa- per, is no longer intuitive. Yet by reconstructing the context in which the categories of digital and analog were first distinguished histori- cally in the ...
openaire +2 more sources
Searching digital music libraries [PDF]
, 2005 There has been a recent explosion of interest in digital music libraries. In particular, interactive melody retrieval is a striking example of a search paradigm that differs radically from the standard full-text search.
Bainbridge, David +2 more
core +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Reflections on digital innovation [PDF]
, 2018 The paper by Henfridsson et al. opens up a new agenda for IS research on the content and process of digital innovation. The crucial element in their perspective is the role of recombination in innovation.
Monteiro, Eric
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Digital communication system [PDF]
, 1974 A digital communication system is reported for parallel operation of 16 or more transceiver units with the use of only four interconnecting wires. A remote synchronization circuit produces unit address control words sequentially in data frames of 16 ...
Monford, L. G., Jr.
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Calle 14: Revista de Investigación en el Campo del Arte, 2014 Esta es la versión EPUB para las tablets y ...
Revista digital
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