Results 71 to 80 of about 10,941,453 (300)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Digital Inequality [PDF]

open access: yes, 2012
Unpicking and understanding if and how the web is linked to inequality means: Recognising that the access divide is not over, Thinking beyond hardware, Thinking beyond demographic variables, Developing a conceptual and theoretical toolkit, Beyond ...
Halford, Susan
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Between digital and physical: some thoughts on digital printmaking [PDF]

open access: yes, 2008
Paper discussing how digital printmaking relates to traditional physical printmaking. The relationship between online image and the physical product and how they fundamentally differ.
Coldwell, Paul
core  

Digital Quantum Estimation

open access: yes, 2017
Quantum Metrology calculates the ultimate precision of all estimation strategies, measuring what is their root mean-square error (RMSE) and their Fisher information. Here, instead, we ask how many bits of the parameter we can recover, namely we derive an
Hassani, Majid   +2 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

DIGIT - DIGItal sTeps

open access: yes, 2016
Despite the great technological evolution felt in recent decades in the media field towards the automation of audio post-production processes that did not occur in the practise of sound foley, which remains a manual process that is based on the technical and interpretive skills of a foley artist.
openaire   +2 more sources

Analogous: Digital / Analogue Metaphors. [PDF]

open access: yes, 2011
When discussing our understanding of the world, the term ‘analogue’ has become shorthand for anything not digital, and has become an analogy of its own. ‘Digital’ has also become an analogy for anything requiring a computer.
Carpenter, Ele
core  

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

open access: yesFEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca   +6 more
wiley   +1 more source

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