Results 71 to 80 of about 10,941,453 (300)
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Unpicking and understanding if and how the web is linked to inequality means: Recognising that the access divide is not over, Thinking beyond hardware, Thinking beyond demographic variables, Developing a conceptual and theoretical toolkit, Beyond ...
Halford, Susan
core
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Between digital and physical: some thoughts on digital printmaking [PDF]
Paper discussing how digital printmaking relates to traditional physical printmaking. The relationship between online image and the physical product and how they fundamentally differ.
Coldwell, Paul
core
Quantum Metrology calculates the ultimate precision of all estimation strategies, measuring what is their root mean-square error (RMSE) and their Fisher information. Here, instead, we ask how many bits of the parameter we can recover, namely we derive an
Hassani, Majid +2 more
core +1 more source
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Despite the great technological evolution felt in recent decades in the media field towards the automation of audio post-production processes that did not occur in the practise of sound foley, which remains a manual process that is based on the technical and interpretive skills of a foley artist.
openaire +2 more sources
Analogous: Digital / Analogue Metaphors. [PDF]
When discussing our understanding of the world, the term ‘analogue’ has become shorthand for anything not digital, and has become an analogy of its own. ‘Digital’ has also become an analogy for anything requiring a computer.
Carpenter, Ele
core
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source

