Results 61 to 70 of about 39,640,380 (305)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Digital Collections and Digital Collecting Practices [PDF]
Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems, 2015 Reference is increasingly made to ‘digital collections’, yet this term encompasses accumulated digital objects of varying form, purpose and value. We review social science literature on mate-rial collections and draw from in-depth interviews with 20 peo-ple in the UK in order to offer a clearer understanding of what constitutes a digital collection and
Rebecca D. Watkins +2 more
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
From the Digitized to the Digital Library
D-Lib Magazine, 2001 Historical Social Research.
openaire +3 more sources
Digital (In)Equality, Digital Inclusion, Digital Humanism
12th ACM Conference on Web Science Companion, 2020 From its inception, the World Wide Web has been intended to be a force for social good. But there are many barriers and obstacles, a situation commonly characterized as the Digital Divide. Several billion people especially in the Global South do not have access to Internet/Web for reasons of lacking (affordable) infrastructure, poverty, low literacy ...
Anna Bon, Hans Akkermans
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Digital Transformation and Digital Leadership [PDF]
Healthcare Informatics Research, 2019 Healthcare does not transform itself; it is transformed by us. The people coming to the Biomedical Informatics society are those who wish to make changes. In my opinion, this is what digital leadership is. Through this article, I will share what is happening in the world around us in terms of Biomedical Informatics.
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Learning by building digital libraries [PDF]
, 2006 The implications of using digital library software in educational contexts, for both students and software developers, are discussed using two case studies of students building digital ...
J. Stephen Downie +7 more
core +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Abstract When discussing the Middle East’s digital turn, it is essential to recognize inherent disjunctures between the predigital and the digital: between “old” media that clings to print publications, radio stations, and satellite television and “new” media that embraces and promotes the use of software, portals, social media, and ...
Mohamed Zayani, Joe F. Khalil
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