Results 81 to 90 of about 12,958,249 (313)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Diagnosing Qur’ānic Precepts on Wealth Creation in Digital Age

Invest Journal of Sharia & Economic Law
This study examines how Islamic economic principles can provide guidance for ethical wealth creation, protection, and distribution in the rapidly evolving digital economy, particularly in the face of cybercrime and financial scams.
Sidiq Uthman Okanlawon, Haruna Zagoon-Sayeed, Taiwo Moshood Salisu   +2 more
doaj   +1 more source

The Humanities in the Digital Age

First Monday, 2008
Bruce Cole, Chairman of the National Endowment for the Humanities, delivered welcoming remarks to participants at the 2008 WebWise Conference on Libraries and Museums in the Digital World in Miami Beach, Florida on March 6, 2008. In his remarks, he discussed the effect that digital technology is having on humanities scholarship and access, and ...
openaire   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Meeting report: “Re-thinking/ re-configuring participation”. Conference, 2021 (online)

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2022
Daniela van Geenen, Katharina Kinder-Kurlanda   +1 more
doaj   +1 more source

Religious Studies Education as a Factor of Societal Religious Security in the Context of Russia's Hybrid War

Cхід
The article is devoted to analyzing the role of religious studies education as one of the key instruments of religious security in countering Russia's religious informational propaganda in its contemporary hybrid wars.
Irina Lomachinska, Svitlana Khrypko, Kristina Binkivska   +2 more
doaj   +1 more source

The Role of Collaboration and Networking in the Digital Age: Students’ Perspectives [PDF]

E-Journal of Humanities, Arts and Social Sciences
In the ever-evolving landscape of the digital age, the dynamics of collaboration and networking have undergone a transformative paradigm shift. This paper delves into the critical role of digital literacy in fostering effective collaboration and ...
Nolizwi Gqwabaza, Thabisa Maqoqa
doaj   +1 more source