Results 61 to 70 of about 3,919,107 (321)

DSpace@Cambridge: implementing long-term digital preservation [PDF]

open access: yes, 2005
This article describes one approach towards digital preservation and long-term accessibility of content in DSpace@Cambridge anno 2005.DSpace@Cambridge is an institutional archive set up to deal with the long-term preservation of information in a wide ...
De Mulder, Tom
core  

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

open access: yesAdvanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia   +14 more
wiley   +1 more source

Digitizing the Archive

open access: yesThe International Journal of Information, Diversity, & Inclusion, 2023
This article explores how digital humanities (DH) projects, specifically the building of digital archives and digital exhibitions, can be implemented to preserve, reveal, and highlight previously invisibilized histories. This piece examines the construction of the Latino/a/x Issues Conference (LIC) archive at Bowling Green State University (BGSU), a ...
openaire   +3 more sources

Intelligent Stain‐Free Histology on Structural Colorimetric Nanocavities

open access: yesAdvanced Science, EarlyView.
Chen and Gan et al. introduce a label‐free imaging platform using inexpensive Nanocavity‐on‐Silicon (NOS) slides. These slides transform subtle tissue variations into vivid structural colors, enabling high‐contrast histological imaging under a regular optical microscope. This stain‐free approach reveals morphological details comparable to traditional H&
Qizhe Chen   +18 more
wiley   +1 more source

From Digital Archive to Digital Edition

open access: yes, 1999
Historical Social Research, 24(1), 101 ...
Aumann, Stefan   +5 more
openaire   +2 more sources

A Digital Archive of H I 21 Centimeter Line Spectra of Optically Targeted Galaxies [PDF]

open access: yes, 2005
We present a homogeneous compilation of H I spectral parameters extracted from global 21 cm line spectra for some 9000 galaxies in the local universe (heliocentric velocity -200 < V☉ < 28,000 km s-1) obtained with a variety of large single-dish radio ...
C. Springob   +3 more
semanticscholar   +1 more source

Extracting, Transforming and Archiving Scientific Data [PDF]

open access: yes, 2011
It is becoming common to archive research datasets that are not only large but also numerous. In addition, their corresponding metadata and the software required to analyse or display them need to be archived. Yet the manual curation of research data can
Lemire, Daniel, Vellino, Andre
core   +1 more source

HiST: Histological Images Reconstruct Tumor Spatial Transcriptomics via MultiScale Fusion Deep Learning

open access: yesAdvanced Science, EarlyView.
HiST, a multiscale deep learning framework, reconstructs spatially resolved gene expression profiles directly from histological images. It accurately identifies tumor regions, captures intratumoral heterogeneity, and predicts patient prognosis and immunotherapy response.
Wei Li   +8 more
wiley   +1 more source

Reassembling digital archives—strategies for counter-archiving

open access: yesHumanities and Social Sciences Communications
AbstractArchives have long been a key concern of academic debates about truth, memory, recording and power and are important sites for social sciences and humanities research. This has been the case for traditional archives, but these debates have accelerated with the digital transformation of archives.
openaire   +3 more sources

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

open access: yesAdvanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy