Results 61 to 70 of about 43,353 (255)

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

The Internet Archive: An Interview with Brewster Kahle

19, 2015
In this interview, founder and director of the Internet Archive Brewster Kahle talks about the cornerstone of modern librarianship: mass digitization. A leading figure in the open access movement, Kahle discusses the creation of the Internet Archive and ...
Ana Parejo Vadillo, Brewster Kahle
doaj   +2 more sources

Retracted: Value Exploration and Application of Digital Archive Information Resources under the Information Ecological Environment. [PDF]

J Environ Public Health, 2023
Environmental And Public Health JO.
europepmc   +1 more source

Dual‐Mode Nanoporous SiO2 Memristors with Coexisting Volatile and Nonvolatile Dynamics for Reservoir Computing

Advanced Science, EarlyView.
A nanoporous SiO2 memristor enabling reconfigurable volatile and non‐volatile switching within a single device is demonstrated. The dual‐mode functionality supports both physical reservoir dynamics and synaptic weight storage, allowing unified hardware implementation of reservoir computing for temporal information processing, including image and ...
Bohao Ding, Tongjun Zhang, Li Shao, Nikolay Zhelev, Andrew L. Hector, Ruomeng Huang   +5 more
wiley   +1 more source

Developing a digital archive system for imperial Chinese robe in the Qing Dynasty. [PDF]

Front Neurosci, 2022
Su M, Li S, Lu Y, Yang L, Duan Y, Xiao K, Pointer M, Luo MR, Liu X.   +8 more
europepmc   +1 more source

Reassembling digital archives—strategies for counter-archiving

Humanities and Social Sciences Communications
AbstractArchives have long been a key concern of academic debates about truth, memory, recording and power and are important sites for social sciences and humanities research. This has been the case for traditional archives, but these debates have accelerated with the digital transformation of archives.
openaire   +5 more sources

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Quel est le goût des archives numériques ? Corps, sens et savoirs archivistiques à l’épreuve de la dématérialisation

Activités
At every level of French territories, the agents in the Archives services must adapt to archive the future of the past in the present. In the era of digitization and digital information, these agents are learning a different way to archive in order to ...
Mathilde Sergent-Mirebault
doaj   +1 more source

Over a Century of Occupational Medicine Research in Italy: La Medicina del Lavoro's Entire Digital Archive is Available Online. [PDF]

Med Lav, 2023
Mutti A, Spatari G.
europepmc   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source