Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
Rural Greece in Transition: Digitalisation, Demographic Dynamics, and Migrant Labour
GeographiesThe paper examines the current landscape, as well as the promises and pitfalls, of the digital transition in agricultural production and rural areas in Greece. It questions whether digitalisation is a viable option given the demographic dynamics, gaps in
Apostolos G. Papadopoulos +3 more
doaj +1 more source
Fragmentation and the digital city: An analysis of Vicente Luis Mora's circular 07. Las afueras [PDF]
, 2019 This essay juxtaposes three recent publications, Vicente Luis Mora's Circular 07. Las afueras (2007-), Kenneth Goldsmith's Capital: New York, Capital of the 20th Century (2015), and Jorge Carrión's Barcelona.
Saum-Pascual, A
core
Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription
Advanced Science, EarlyView.This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen +14 more
wiley +1 more source
Exploring Media Literacy Formation at the Intersection of Family, School, and Peers
Media and CommunicationToday, media literacy and digital skills are essential for personal communication and social interaction. Children and adolescents need these skills to act autonomously in highly digitised social contexts.
Nika Šušterič +2 more
doaj +1 more source
Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source
Disability citizenship and digital capital: the case of engagement with a social enterprise telco
Information, Communication & Society, 2018 This paper uses as its base a key initiative involving a not-for-profit organisation (NPO), government start-up funding and a social enterprise which evolved through three phases.
S. Darcy, H. Yerbury, H. Maxwell
semanticscholar +1 more source
Using Digital Art to make the Tension beetween Capital and Commons Transparent. Innovation in shaping knowledge of Internet business practices as a form of cultural knowledge\ud [PDF]
, 2012 This paper examines a digital art performance by Ubermorgen.com called Google Will Eat Itself (GWEI.org) as an example of the tensions between Capital and the public commons.
Kampf, Constance E.
core
Contingency and Satisfaction under Digital Capitalism [PDF]
Stream: Interdisciplinary Journal of Communication, 2016 Explorations into today's labour context reveal a wide schism between those workers who live under conditions of precarity and contingency and those who seem to be living the dream - and not only in terms of wages. The standardized work day and Taylorized division of labour that characterized most of the industrial era has transitioned, at least in ...
openaire +2 more sources
Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium
Advanced Science, EarlyView.This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du +5 more
wiley +1 more source