Results 121 to 130 of about 128,849 (300)

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

FORMATION OF FUTURE MATHEMATICS TEACHERS’ DIGITAL COMPETENCE: ASCERTAIN STAGE

Інформаційні технології і засоби навчання, 2018
The article is devoted to determination of the levels of the digital competence of future mathematics teachers at the ascertaining stage of the pedagogical experiment. A scientific analysis of the essence of the notion «digital competence» is carried out,
Oleksandr H. Romanovskyi, Valentyna M. Grineva, Oksana A. Zhernovnykova, Liudmyla A. Shtefan, Vasyl V. Fazan   +4 more
doaj  

Configurational Analysis of the Driving Paths of University EFL Teachers’ Digital Competence

SAGE Open
This study examines the configurational factors influencing digital competence among university foreign language teachers using fuzzy-set qualitative comparative analysis (fsQCA). Specifically, it investigates how technological factors (perceptions of AI)
Ling Jin, Maojie Zhou
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

The Impact of Corporate Venturing on a Firm’s Competence Modes [PDF]

In this conceptual paper we investigate how corporate venturing influences an organization’s competences. The impact of various types of corporate ventures on the portfolio of strategic options of a firm’s competence modes (Sanchez, 2004a; Sanchez ...
Volberda, H.W., Burgers, J.H., Bosch, F.A.J. van den   +2 more
core   +1 more source

Unveiling University Students’ Perceptions on Their Teachers’ Digital Competence [PDF]

In contemporary society, digital competence has become increasingly important for people in everyday life as well as in working life. Hence, it is vital that today’s higher education contain an appropriate degree of digitization both in terms of content ...
Tell, Joakim,, Hoveskog, Maya,, Cherni, Wiem,, Maya Hoveskog, Joakim Tell, Sjöberg, Jeanette,, Jeanette Sjöberg, Wiem Cherni   +7 more
core   +1 more source

Digital competence – A Key Competence for Todays and Future Physicians [PDF]

Journal of European CME, 2022
Nilufar Foadi, Julian Varghese
openaire   +3 more sources

Digital Competence of Educators in Turkey According to European Digital Competence Framework

Journal of Learning and Teaching in Digital Age
Nowadays, it is not common to come across sectors that can work and succeed without using information technology (IT). IT has now become a part of organizations' management and strategic decision-making mechanisms. Therefore, organizations make serious investments to develop software and system infrastructures and transfer business processes to digital
Zafer KUŞ, Hilal MERT
openaire   +2 more sources