Results 101 to 110 of about 37,831,570 (299)

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Bibliometric analysis and systematic review of digital competence in education

Humanities & Social Sciences Communications
The ubiquity of digital technologies has profoundly transformed communication and education in the 21st century, making the development of digital competence essential for both teachers and students to be prepared for the digital age.
Huiling Ma, Lilliati Ismail
doaj   +1 more source

Macroassessment of teachers’ digital competence. DigCompEdu study in Spain and Portugal

RIED: Revista Iberoamericana de Educación a Distancia
Teachers’ digital competence is essential in contemporary education due to the growing role of technology in society, schools, and classrooms. This study examines teachers’ digital competence in the context of the Iberian Peninsula, covering 170,603 in ...
Antonio Palacios-Rodríguez, Carmen Llorente-Cejudo, Margarida Lucas, Pedro Bem-haja   +3 more
doaj   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Assessing the digital competence and its influencing factors among foreign language teachers in Chinese universities

Humanities & Social Sciences Communications
This study empirically investigates the current status of the digital competence of 582 foreign language teachers in universities across the eastern, central, and western regions in China. The results indicate that the questionnaire based on the Ministry
Hong Lei, Zhanhao Jiang
doaj   +1 more source

Teachers’ Epistemic Beliefs and Digital Competence

MedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung
Recent research in media education has increasingly emphasized how teachers’ epistemic beliefs and digital learning beliefs shape instructional practices and the development of teachers’ digital competence. Drawing on survey data from 156 in-service and
Maximilian Sailer, Xinlei Sun, Julia Watzinger, Detlef Urhahne   +3 more
doaj   +1 more source

Digital competence and teacher education: teacher identity, tensions and agency

In response to the transformative impact of technology on global society, education must adapt to meet the changing needs of learners. However, as technologies evolve, so do the competencies and skill sets teachers need to be effective in integrating ...
Trevisan, Ottavia
core   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source