Results 101 to 110 of about 578,837 (306)

Postgraduate education system as an environment for the development of digital competence of an art teacher

CTE Workshop Proceedings
The article analyzes scientific approaches to interpreting the concepts of "digital competence" and "digital competence of an art teacher". It examines the core characteristics of digital competence as defined in domestic regulatory documents and ...
Liudmyla H. Kondratova
doaj   +1 more source

Health and Social Care Educators’ Competence in Digital Collaborative Learning: A Cross-Sectional Survey

SAGE Open, 2020
The ongoing change from traditional pedagogy to digital collaborative learning requires a new mode of teaching, learning, and educators’ responsibilities.
Merja Männistö, Kristina Mikkonen, Heli-Maria Kuivila, Camilla Koskinen, Meeri Koivula, Tuulikki Sjögren, Leena Salminen, Terhi Saaranen, Helvi Kyngäs, Maria Kääriäinen   +9 more
doaj   +1 more source

‘Managing pieces of a personal puzzle’ — older people’s experiences of self-management falls prevention exercise guided by a digital program or a booklet [PDF]

, 2019
Background: Exercise is effective in order to prevent falls in community-dwelling older people. Self-management programs have the potential to increase access and reduce costs related to exercise-based fall prevention.
Helena Lindgren, Helena, Janols, Rebecka, Lundin-Olsson, Lillemor, Pettersson, Beatrice, Sandlund, Marlene, Skelton, Dawn, Wiklund, Maria   +6 more
core   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

The one minute mentor : a pilot study assessing medical students’ and residents’ professional behaviours through recordings of clinical preceptors’ immediate feedback [PDF]

, 2009
Introduction: The assessment of professional development and behaviour is an important issue in the training of medical students and physicians. Several methods have been developed for doing so.
Ellaway, Rachel, Evans, Rebecca, Nan Tie, Rod, Thistlethwaite, Jill, Topps, D.   +4 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Digital Competence Education students [PDF]

, 2014
Esta investigación que ahora presentamos ha sido llevada a cabo con estudiantes universitarios de la Facultad de Educación de Ciudad Guayana (Venezuela).
Gutiérrez Castillo, Juan Jesús, Gómez del Castillo Segurado, María Teresa   +1 more
core  

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Digital competences in the field of higher education: conception, realization, result [PDF]

, 2019
У статті обґрунтовано сутність цифровізації освіти, як такої, що базується на використанні в освітньому процесі цифрових комп’ютерних технологій. Зміст цифрової компетентності обґрунтовано з урахуванням того, що вона включає критичне й відповідальне ...
Болдирєва, Людмила Миколаївна, Краус, Катерина Миколаївна, Краус, Наталія Миколаївна   +2 more
core  

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source