Results 151 to 160 of about 35,521,183 (298)

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

open access: yesAdvanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo   +10 more
wiley   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

open access: yesAdvanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li   +9 more
wiley   +1 more source

Digital Competencies for Nurses: Tools for Responding to Spiritual Care Needs. [PDF]

open access: yesHealthcare (Basel), 2022
Burgos D   +4 more
europepmc   +1 more source

Individual entrepreneurial orientation and digital entrepreneurial intention: examining the mediating role of digital competencies

open access: yes
Purpose. This study explores the relationship between individual entrepreneurial orientation and digital entrepreneurial intention, focusing on the potential mediating role of digital competencies within the framework of Social Cognitive Theory ...
Lohse, Hendrik Udo   +3 more
core   +1 more source

Information, Competencies and Collaborative Teaching/Learning [PDF]

open access: yes, 2002
The purpose of this paper is to survey the literature about current trends on several issues concerning technical information education including: 1. Information needs, user behaviors, access and availability of engineering information resources.
Osorio, Nestor L.
core  

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

open access: yesAdvanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou   +6 more
wiley   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

open access: yesAdvanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang   +6 more
wiley   +1 more source

Digital research competencies [PDF]

open access: yes
Швидкі темпи розвитку технологій вимагають від дослідників постійного оновлення своїх навичок та знань. Наприклад, нові інструменти для аналізу даних, платформи для співпраці, програмні забезпечення для моделювання та візуалізації значно змінюють підходи
Франчук, Н.П.
core   +1 more source

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