Results 41 to 50 of about 50,553,671 (303)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Comparación de Métodos de Reducción de Dimensión Basados en Análisis por Localidades

open access: yesTecnoLógicas, 2010
In this paper, a comparison of methods for nonlinear dimensionality reduction is proposed in order to determine which technique preserves better the local properties, without losing the overall structure of the original data.
Juliana Valencia-Aguirre   +3 more
doaj  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Liquor control decision; State of Connecticut, Department of Consumer Protection, before the Liquor Control Commission

open access: yes, 2009
Irregular; Some issues lack docket or permit number.; Prepared for Connecticut. Liquor Control Commission by Connecticut.
Connecticut. Liquor Control Commission.
core   +1 more source

A High Efficiency Interleaved PFC Front - End Converter for EV Battery Charger

open access: yesCommunications, 2018
Nowadays, an increasingly present application in the automotive field is the battery charger that usually consists of two high efficiency parts: an AC/DC converter with power factor correction (PFC) capability and a DC/DC converter.
Giuseppe Aiello   +3 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Selección de Características 2D en Representaciones Tiempo Frecuencia para la Detección de Soplos Cardíacos

open access: yesTecnoLógicas, 2011
En el presente trabajo se propone una metodología para la reducción de dimensión en representaciones tiempo frecuencia (TFRs) enfocada a la clasificación de bioseñales no estacionarias, que trata directamente su cantidad de datos irrelevantes y ...
Juan D. Martínez-Vargas   +2 more
doaj  

Digital Control Scheme for Class-D Power Amplifier Driving ICP Load Without Matching Network

open access: yesEnergies
Class-D power amplifiers driving variable loads, such as inductively coupled plasma (ICP), typically require an impedance matching network, which has a relatively slow matching speed, generally in the millisecond range.
Fuchao Lu, Zhengquan Zhang
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

open access: yesMolecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan   +8 more
wiley   +1 more source

Liquor control decision; State of Connecticut, Department of Consumer Protection, before the Liquor Control Commission

open access: yes, 2007
Irregular; Some issues lack docket or permit number.; Prepared for Connecticut. Liquor Control Commission by Connecticut.
Connecticut. Liquor Control Commission.
core   +1 more source

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