Results 51 to 60 of about 1,282,265 (246)

Digital control and the problem of freedom in the information society [PDF]

Известия Саратовского университета. Новая серия: Серия Философия. Психология. Педагогика
Introduction. This article examines the problem of digital control as a tool for coercion and manipulation of citizens, depriving them of freedom and personal space.
Kraynov, Andrey Leonidovich
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Energy Internet via Packetized Management: Enabling Technologies and Deployment Challenges

IEEE Access, 2019
This paper investigates the possibility of building the energy Internet via a packetized management of non-industrial loads. The proposed solution is based on the cyber-physical implementation of energy packets, where flexible loads send user requests to
Pedro H. J. Nardelli, Hirley Alves, Antti Pinomaa, Sohail Wahid, Mauricio De Castro Tome, Antti Kosonen, Florian Kuhnlenz, Ari Pouttu, Dick Carrillo   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mathematical Model and Digital Control of a Twin Power Converter [PDF]

Journal of Electrical and Electronics Engineering
In spite of latest remarkable technological achievements reached in electronic devices and converters development, faults in power electronics remains unavoidable.
SZÁSZ Csaba
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A Low-Cost Evaluation Tool for Synchronization Methods in Three-Phase Power Systems

Applied Sciences
The use of renewable energy sources (RESs) together with energy storage systems (ESSs) allows for smoothing power variations, thus improving power backup capabilities and power quality in the electric power grid.
Marcelo E. Reyes, Pedro E. Melin, Eduardo Espinosa, Carlos R. Baier, Cristian Pesce, Benjamín Cormack   +5 more
doaj   +1 more source

DES Supervisor realization of the Safe Switching Mechanism of Soft-Sensors [PDF]

MATEC Web of Conferences
A supervisory scheme is proposed, toward the Discrete Event Systems (DES) realization of the safe switching architecture for a bank of observers composing soft sensors for water distribution networks (WDNs).
Tzamtzi Maria P., Koumboulis Fotis N., Kouvakas Nikolaos D., Fragkoulis Dimitrios G.   +3 more
doaj   +1 more source