Results 21 to 30 of about 282,025 (223)

The Collaboration and Application of Digital Content Curation in the University Archives

Tūzī yǔ dàng’àn xuékān, 2018
Digital content curation refers to the process of concentrating, extracting, insighting, mashing and serializing digital resources based on the theme through a screening mechanism, and presenting high-quality content with a single or combined method ...
Ching-Fei Huang, Chih-Ming Chen
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

The Copyrights Chain in the Digital Curation Process

International Journal of Digital Curation
The internet era, open access movement, image sharing platforms, and mainly the rise of artificial intelligence (AI) emphasise the importance of providing moderated access and licences for the reuse of collections by memory institutes as a key step in ...
Keren Barner
doaj   +1 more source

Digital Curation as a Core Competency in Current Learning and Literacy: A Higher Education Perspective

International Review of Research in Open and Distributed Learning, 2016
Digital curation may be regarded as a core competency in higher education since it contributes to establishing a sense of metaliteracy (an essential requirement for optimally functioning in a modern media environment) among students.
Leona M. Ungerer
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Curating the digital

CHI '14 Extended Abstracts on Human Factors in Computing Systems, 2014
This workshop intends to use the key strength of the CHI Community; research linked to practice, to design an Art Catalog for CHI. The workshop will start with an examination of current research in curating interactive art. The outcomes of the first phase of the workshop will then feed into Design Charrette exercises that will involve prototyping an ...
England, D, Spence, J, Latulipe, C, Edmonds, E, Candy, L, Schiphorst, T, Bryan-Kinns, N, Woolford, K   +7 more
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Personal Archive Management with Digital Curation Concept on Students’ Smartphones

Record and Library Journal, 2019
Bckground of the study: Digital curation activities are necessary for organizing digital archives to be accessible to the present and future. The problem in this research is that information and library management (MIP) students who have previously ...
Santana Sembiring, Khairunnisa Khairunnisa, Leila Kurnia   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Public Domain; Public Interest; Public Funding: focussing on the ‘three Ps’ in scientific research

SCRIPTed: A Journal of Law, Technology & Society, 2005
The purpose of this paper is to discuss the ‘three Ps’ of scientific research: Public Domain; Public Interest; Public Funding. This is done by examining some of the difficulties faced by scientists engaged in scientific research who may have problems ...
Charlotte Waelde and Mags McGinley
doaj   +1 more source