Results 41 to 50 of about 9,934 (258)

Digital Currency in Broader Sense, Status, Regulation and Development Trends

open access: yesFinancial Law Review, 2021
The present article deals with one of the phenomena of the Industrial (Digital) revolution 4.0, which is digital currency in broader sense, respectively virtual currencies, as some authors refer to ...
Miroslav Štrkolec, Ladislav Hrabčák
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

TRADITIONAL CRYPTOCURRENCIES AND FIAT-BACKED DIGITAL CURRENCIES [PDF]

open access: yesChallenges of the Knowledge Society, 2021
The digital payments space saw vigorous investment activity during 2020 and there have been a plethora of announcements about account based Central Bank Digital Currencies.
Serghei MĂRGULESCU, Elena MĂRGULESCU
doaj   +2 more sources

The Impact of Central Bank Digital Currency on Rural Revitalization: An Empirical Analysis of Data from 284 Cities in China

open access: yesSAGE Open
As legal tender created using advanced digital technology, Central Bank Digital Currency provides new opportunities for driving rural revitalization. This paper empirically assesses the impact of Central Bank Digital Currency on rural revitalization by ...
Muchen Li, Shining Guo, Qianyi Zhang
doaj   +1 more source

AN IDEAL LEGAL TENDER FOR THE DIGITAL ERA

open access: yesJournal of Central Banking Law and Institutions, 2023
The Covid-19 pandemic has accelerated a shift towards digital payments and altered consumer behaviour when it comes to making payments. As a result, the use of state-issued money as legal tender continues to decline in most countries.
Fransiska Ari Indrawati
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Foreign experience in defining the legal framework, implementation and research of digital currencies

open access: yesУченые записки Российской академии предпринимательства
Digital currencies of national banks are becoming more and more tightly integrated into the modern reality. Many countries around the world are at different stages of creating, piloting and implementing digital currencies. Undoubtedly, digital currencies
E. M. Musatov   +2 more
doaj   +1 more source

FOREIGN EXCHANGE MARKETS AND OPERATIONS IN THE CONTEXT OF DIGITALIZATION

open access: yesВестник Северо-Кавказского федерального университета, 2022
The article discusses the theoretical foundations of the functioning of currency markets. Classification of types of currency transactions according to the legislation of the Russian Federation is given.
J. Konopleva, O. Pakova, K. Gavrilov
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

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