Results 41 to 50 of about 5,768,137 (296)

The digital data processing concepts of the LOFT mission

, 2014
The Large Observatory for X-ray Timing (LOFT) is one of the five mission candidates that were considered by ESA for an M3 mission (with a launch opportunity in 2022 - 2024).
Argan, A., Cros, A., Favre, Y., Gschwender, M., Jetter, F., Santangelo, A., Schanne, S., Smith, P., Suchy, S., Tenzer, C., Uter, P., Walton, D., Wende, H.   +12 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Accelerating Pinned Insect Specimen Digitization: A Deep Learning Pipeline for Future Collaborative Robots

Advanced Intelligent Systems
The Natural History Museum, UK (NHM), is at the forefront of digitizing vast natural history collections, with over six million of its 80 million specimens already digitized.
Naifeng Zhang, Arianna Salili‐James, Sanson T. S. Poon, Jack D. Hollister, Ben Scott   +4 more
doaj   +1 more source

Digital decoder for phase-delay coded data [PDF]

, 1971
Coded or modulated digital data converts to nonreturn to zero /NRZ/ data. Technique includes logic implementation and pertinent timing diagrams. Demodulation to NRZ facilitates digital logic operations on incoming data.
Lewin, J.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATCodeR: a dictionary-based R-tool to standardize medication free-text

Scientific Reports
Over the past decades, oncology treatment paradigms have developed significantly. Yet, the often unstructured nature of substance-related documentation in medical records presents a time-consuming challenge for analyzing treatment patterns and outcomes ...
Isabel Schnorr, Stefanie Andreas, Linnea Schumann, Svenja Hahn, Jörg Janne Vehreschild, Daniel Maier   +5 more
doaj   +1 more source

Glaucoma Identification Using Convolutional Neural Networks Ensemble for Optic Disc and Cup Segmentation

IEEE Access
Glaucoma is one of the diseases that can cause incurable blindness. The first noticeable symptoms appear only when the disease has progressed but an early diagnosis of the disease prevents the severe consequences of disease progression. In this paper, we
Sandra Virbukaite, Jolita Bernataviciene, Daiva Imbrasiene   +2 more
doaj   +1 more source

LODE: Linking Digital Humanities Content to the Web of Data

, 2014
Numerous digital humanities projects maintain their data collections in the form of text, images, and metadata. While data may be stored in many formats, from plain text to XML to relational databases, the use of the resource description framework (RDF ...
Allen, Colin, Huber, Jakob, Murdock, Jaimie, Niepert, Mathias, Noessner, Jan, Sztyler, Timo   +5 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Responsible AI innovation in the public sector: Lessons from and recommendations for facilitating Fundamental Rights and Algorithms Impact Assessments

Journal of Responsible Technology
Since the initial development of the Fundamental Rights and Algorithms Impact Assessment (FRAIA) in 2021, there has been an increasing interest from public sector organizations to gain experience with performing a FRAIA in contexts of developing ...
I.M. Muis, J. Straatman, B.A. Kamphorst
doaj   +1 more source