Results 51 to 60 of about 5,768,137 (296)

Causal Interactions in Agile Application Development

Mathematics, 2022
The Agile approach and tools are popular for the management of Enterprise Application Software (EAS) development. This article focuses on the issue of inconsistency between strategic business objectives and the functionality of the software developed ...
Saulius Gudas, Karolis Noreika
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Reviewing the lines of therapy-concept in cancer treatment: a survey study among physicians

BMC Cancer
Background While the line of therapy (LOT) concept is crucial for clinical decision-making in oncology, the concept lacks a consensual understanding bearing the risk of miscommunication. This study examines physicians’ understanding of LOT, its perceived
Lisa M. M. Falchetto, Bernd Bender, Ian Erhard, Stefanie Andreas, Linnea L. I. Schumann, Isabel Schnorr, Karin Berger-Thürmel, Jörg Janne Vehreschild, Daniel Maier   +8 more
doaj   +1 more source

Digital data transition tracking loop improves data reception [PDF]

, 1970
Transition tracking loop eliminates drifts, leakages, and instabilities inherent in analog filters.
Anderson, T. O., Hurd, W. J., Lindsey, W. C.   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson’s disease

Nature Communications
Parkinson’s disease is highly heterogeneous across disease symptoms, clinical manifestations and progression trajectories, hampering the identification of therapeutic targets.
Abolfazl Doostparast Torshizi, Dongnhu T. Truong, Liping Hou, Bart Smets, Christopher D. Whelan, Shuwei Li   +5 more
doaj   +1 more source

Exploring Multidimensional Embeddings for Decision Support Using Advanced Visualization Techniques

Informatics
As artificial intelligence has evolved, deep learning models have become important in extracting and interpreting complex patterns from raw multidimensional data.
Olga Kurasova, Arnoldas Budžys, Viktor Medvedev   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Analysis of Education Systems Performance in European Countries by Means of PCA-DEA

Informatics in Education, 2018
Many countries have focused on the improvement of education system performance. Small number of studies consider system of a country as unit of assessment where indicators represent all levels of education system. In the paper, we propose the methodology
Audrone JAKAITIENE, Antanas ZILINSKAS, Dovile STUMBRIENE   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source