Results 71 to 80 of about 5,768,137 (296)

Trusty URIs: Verifiable, Immutable, and Permanent Digital Artifacts for Linked Data [PDF]

, 2014
To make digital resources on the web verifiable, immutable, and permanent, we propose a technique to include cryptographic hash values in URIs. We call them trusty URIs and we show how they can be used for approaches like nanopublications to make not ...
A. Callahan, F. Belleau, J. Broekstra, J.J. Carroll, J.P. McCusker, J.P. McCusker, M. Altman, M. Bellare, P. Groth, R. Hoekstra, R.C.W. Phan, T. Kuhn, T. Kuhn   +12 more
core   +4 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Enhancing credit card fraud detection: highly imbalanced data case

Journal of Big Data
In the contemporary landscape, fraud is a widespread challenge in today’s financial landscape, requiring innovative methods and technologies to detect and prevent losses from the sophisticated tactics used by fraudsters.
Dalia Breskuvienė, Gintautas Dzemyda
doaj   +1 more source

Matheuristic approaches for multi-product 3-dimensional container loading problem

Applied Operations and Analytics
The problem of packing cases in three-dimensional space in a space-efficient manner is a challenging optimization problem that has wide application in supply-chain and logistics planning across various industries where physical products must be loaded ...
Riddhesh Nitin Kumtakar, Nitish Umang, Gary R. Kocis, Dean W. Face, Chrysanthos E. Gounaris   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Development and deployment of a histopathology-based deep learning algorithm for patient prescreening in a clinical trial

Nature Communications
Accurate identification of genetic alterations in tumors, such as Fibroblast Growth Factor Receptor, is crucial for treating with targeted therapies; however, molecular testing can delay patient care due to the time and tissue required.
Albert Juan Ramon, Chaitanya Parmar, Oscar M. Carrasco-Zevallos, Carlos Csiszer, Stephen S. F. Yip, Patricia Raciti, Nicole L. Stone, Spyros Triantos, Michelle M. Quiroz, Patrick Crowley, Ashita S. Batavia, Joel Greshock, Tommaso Mansi, Kristopher A. Standish   +13 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The taxonomic composition and chronology of a museum collection of Coleoptera revealed through large-scale digitisation

Frontiers in Ecology and Evolution
IntroductionHistoric museum collections hold a wealth of biodiversity data that are essential to our understanding of the rapidly changing natural world.
Beulah H. Garner, Beulah H. Garner, Beulah H. Garner, Thomas J. Creedy, Thomas J. Creedy, Thomas J. Creedy, Elizabeth L. Allan, Robyn Crowther, Elizabeth Devenish, Phaedra Kokkini, Laurence Livermore, Krisztina Lohonya, Nicola Lowndes, Peter Wing, Alfried P. Vogler, Alfried P. Vogler   +15 more
doaj   +1 more source

Stewardship of very large digital data archives [PDF]

This paper addresses the problems foreseen by the author in stewarding the very large digital data archives that will accumulate during the mission of the Earth Orbiting Satellite (EOS).
Savage, Patric
core   +4 more sources