Results 41 to 50 of about 920,360 (339)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Digital Divide| Max Weber and Digital Divide Studies — Introduction
International Journal of Communication, 2015 Seminal sociologist Max Weber rarely wrote about media dynamics; however, the Weberian perspective offers rich potential for the analysis of various media issues, including the study of digital divides.
Massimo Ragnedda, Glenn W. Muschert
doaj
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Teaching with wikis: addressing the digital divide [PDF]
, 2008 This paper addresses some aspects of the digital divide affecting teachers and learners in higher education. These relate to divisions arising from variable rates of technology adoption by teachers, which may be especially problematic when students ...
Benson, Robyn +2 more
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Logic circuit detects both present and missing negative pulses in superimposed wave trains [PDF]
, 1967 Pulse divide and determination network provides a logical determination of pulse presence within a data train. The network uses digital logic circuitry to divide positive and negative pulses, to shape the separated pulses, and to determine, by means of ...
Rice, R. E.
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The study of the relation between smart phone usage and digital divide in Tehran [PDF]
مطالعات رسانههای نوین, 2016 Nowadays, many Iranians are using smart phones. Also, the digital divide problem remains an important issue in contemporary urban Iran. Thus, doing research into the relation between these variables is necessary to provide a better understanding of the ...
Babak Rahimi +3 more
doaj +1 more source
, 2008 Considers the future of libraries in a Web 2.0 world. Looks at how libraries have responded to technological change historically; argues in favour of Prensky's digital native/digital immigrant divide and a fundamental change in user behaviour.
Law, Derek
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source