Results 31 to 40 of about 139,075 (261)

La médiation patrimoniale à l’épreuve du « numérique » : médiation patrimoniale, médiation documentaire et médiation expérientielle

open access: yesRevue Française des Sciences de l’Information et de la Communication, 2019
This article develops a dialectical questioning between the technological injunctions addressed to the cultural field of heritage so that it integrates digital devices, and the patrimonial experience actually proposed by these devices.
Marie Cambone
doaj   +1 more source

DOCUMENTING THE CONSERVATIVE EVOLUTION OF THE CITY WALLS THANKS TO THE INTEGRATION OF DIGITAL SYSTEMS OF VARIOUS TYPOLOGIES. THE CASE STUDY OF VALBONA GATE [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
The presented study describes how to document in a dynamic way a complex and full of historical information architecture with a flexible system. Thanks to the collaboration between various professional figures and the integration of various digital ...
L. Baratin   +4 more
doaj   +1 more source

Artefacts and Errors: Acknowledging Issues of Representation in the Digital: Imaging of Ancient Texts [PDF]

open access: yes, 2011
It is assumed, in palaeography, papyrology and epigraphy, that a certain amount of uncertainty is inherent in the reading of damaged and abraded texts.
Terras, Melissa M.
core   +1 more source

Demanding stories: television coverage of sustainability, climate change and material demand [PDF]

open access: yes, 2017
This paper explores the past, present and future role of broadcasting, above all via the medium of television, in shaping how societies talk, think about and act on climate change and sustainability issues.
Allwood JA   +17 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Principles for the construction and implementation of an integrated electronic document management system

open access: yesВестник Дагестанского государственного технического университета: Технические науки, 2022
Objective. Formulate the general principles for the construction and operation of an integrated electronic document management system, as well as list the possibilities of document management automation.Method.
A. L. Zolkin, V. S. Tormozov
doaj   +1 more source

Data fluidity in DARIAH -- pushing the agenda forward [PDF]

open access: yes, 2016
This paper provides both an update concerning the setting up of the European DARIAH infrastructure and a series of strong action lines related to the development of a data centred strategy for the humanities in the coming years.
Baillot, Anne   +2 more
core   +6 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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