Results 251 to 260 of about 4,502,468 (335)

Digital Editing and Pedagogy

open access: yesScholarly Editing
John Bryant   +3 more
openaire   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

open access: yesThe FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez   +7 more
wiley   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

open access: yesThe FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati   +4 more
wiley   +1 more source

The Healthy Brain Initiative-expanding public health capacity to address dementia. [PDF]

open access: yesGerontologist
Fadel M   +5 more
europepmc   +1 more source

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