Results 71 to 80 of about 4,502,468 (335)
Advanced Science, EarlyView.ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu +12 more
wiley +1 more source
Advanced Science, EarlyView.This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang +21 more
wiley +1 more source
Researching childhood in a digital age: new book chapter [PDF]
, 2017 In the new edition of one of the key methods texts in childhood research – Research with children: Perspectives and practices, edited by Pia Christensen and Allison James – Sonia Livingstone and Alicia Blum-Ross argue that paying attention to the digital
Blum-Ross, Alicia, Livingstone, Sonia
core
Electronic Broadway Project [PDF]
, 2010 The Electronic Broadway Project, based at the Maryland Institute for Technology in the Humanities (MITH), seeks to create an interface for electronic editions of musical theater texts and, as a prototype, develop an electronic edition of the new Broadway
Douglas Reside, Douglas Reside
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Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor
Advanced Science, EarlyView.Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang +4 more
wiley +1 more source
Human rights and the digital edition [PDF]
, 2014 Ha querido entenderse internet como un medio de comunicación de masas más. Se ha tomado como cómplice también de la hiperrealidad, cambiándole a Baudrillard sus referentes, confundiéndolo con la realidad virtual, sin hacer caso de su estructura ...
Ferrari Nieto, Enrique
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Advanced Science, EarlyView.Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner +14 more
wiley +1 more source
Hacia un modelo de edición crítica digital del teatro de Lope [PDF]
, 2015 El artículo presenta un proyecto en curso de edición digital de La dama boba de Lope de Vega. Se describen las principales soluciones encontradas hasta el momento y las razones que han llevado a adoptarlas, y se explican el contexto de realización y los ...
Presotto, Marco
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Advanced Science, EarlyView.The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong +13 more
wiley +1 more source
Farmers’ Protests in Germany: Media Coverage and Types of Bias
Agribusiness, EarlyView.ABSTRACT The German farmers’ protests of 2024 sparked widespread media coverage and public debate. Yet, media coverage was not always positive, reflecting the media's attention‐seeking and selective focus. Occurrences of farmers blocking media outlets reflected distrust in how their concerns were portrayed.
Felix Schlichte, Doris Läpple
wiley +1 more source