Results 61 to 70 of about 1,016,336 (353)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Digital elevation model quality on digital soil mapping prediction accuracy

open access: yesCiência e Agrotecnologia
Digital elevation models (DEM) used in digital soil mapping (DSM) are commonly selected based on measures and indicators (quality criteria) that are thought to reflect how well a given DEM represents the terrain surface.
Elias Mendes Costa   +2 more
doaj   +1 more source

Height Accuracy of Radargrammetric Generated Digital Elevation Model [PDF]

open access: yes, 2002
The stereoscopic concept used in photogrammetry was successfully extended to the optical sensor of SPOT (System Probatoire d'Observation de la Terre) to generate the digital elevation model (DEM) and to extract the planimetric features. Following this
Abdul Samad, Abdul Hadi
core  

Airborne photogrammetry and LIDAR for DSM extraction and 3D change detection over an urban area : a comparative study [PDF]

open access: yes, 2013
A digital surface model (DSM) extracted from stereoscopic aerial images, acquired in March 2000, is compared with a DSM derived from airborne light detection and ranging (lidar) data collected in July 2009.
De Maeyer, Philippe   +4 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Avaliação de Modelos Digitais de Elevação para Estudos Geoecológicos no Maciço da Pedra Branca, Rio de Janeiro, Brasil. [PDF]

open access: yesAnuário do Instituto de Geociências, 2009
Geoprocessing tools have been increasingly used to support the integrated study of geoecological variables, once they allow fast and efficient analysis.
Pedro Henrique Ferreira Coura   +3 more
doaj  

Modeling physical and chemical climate of the northeastern United States for a geographic information system [PDF]

open access: yes, 1995
A model of physical and chemical climate was developed for New York and New England that can be used in a GIs for integration with ecosystem models.
Aber, John D.   +4 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Automated Generation of Digital Terrain Model using Point Clouds of Digital Surface Model in Forest Area

open access: yesRemote Sensing, 2011
At present, most of the digital data acquisition methods generate Digital Surface Model (DSM) and not a Digital Elevation Model (DEM). Conversion from DSM to DEM still has some drawbacks, especially the removing of off terrain point clouds and ...
Yoshikazu Kamiya   +3 more
doaj   +1 more source

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