Results 71 to 80 of about 980,187 (352)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
A new digital elevation model of Antarctica derived from CryoSat-2 altimetry
, 2017 . We present a new digital elevation model (DEM) of the Antarctic ice sheet and ice shelves based on 2.5×108 observations recorded by the CryoSat-2 satellite radar altimeter between July 2010 and July 2016.
T. Slater +7 more
semanticscholar +1 more source
Estimating Coastal Digital Elevation Model Uncertainty
Journal of Coastal Research, 2018 Amante, C.J., 2018. Estimating coastal digital elevation model uncertainty. Integrated bathymetric–topographic digital elevation models (DEMs) are representations of Earth's solid surface that extend across the coastal land–water interface.
C. Amante
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Ecology and Evolution, 2018 Sea‐level rise (SLR) impacts on intertidal habitat depend on coastal topology, accretion, and constraints from surrounding development. Such habitat changes might affect species like Belding's savannah sparrows (Passerculus sandwichensis beldingi; BSSP),
Jordan A. Rosencranz +11 more
doaj +1 more source
Using Lidar Data to Analyse Sinkhole Characteristics Relevant for Understory Vegetation under Forest Cover\u2014Case Study of a High Karst Area in the Dinaric Mountains [PDF]
, 2015 In this article, we investigate the potential for detection and characterization of sinkholes under dense forest cover by using airborne laser scanning data.
Igor, Dakskobler +4 more
core +4 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
A Versatile Processing Chain for Experimental TanDEM-X Product Evaluation [PDF]
, 2010 TanDEM-X is a high-resolution interferometric mission with the main goal of providing a global digital elevation model (DEM) of the Earth surface by means of single-pass X-band SAR interferometry.
Krieger, Gerhard +6 more
core
Ecological model to predict potential habitats of Oncomelania hupensis, the intermediate host of Schistosoma japonicum in the mountainous regions, China [PDF]
, 2015 Schistosomiasis japonica is a parasitic disease that remains endemic in seven provinces in the People's Republic of China (P.R. China). One of the most important measures in the process of schistosomiasis elimination in P.R.
Liu, Lu +3 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source