Results 41 to 50 of about 41,608,755 (248)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Development of an Online Reporting Interface to Detect and Reduce Animal Abuse Cases

Biology and Life Sciences Forum
Animal abuse, encompassing active cruelty and neglect, is an underreported animal welfare and public safety concern. In Hungary, the parallel administrative and criminal law definitions of animal cruelty create additional uncertainty for citizens ...
Annamária Kiss, Gábor Lorászkó, Kinga Fodor   +2 more
doaj   +1 more source

Regulatory Qualification of a Cross-Disease Digital Measure: Benefits and Challenges from the Perspective of IMI Consortium IDEA-FAST

Digital Biomarkers, 2023
Background: Innovative Medicines Initiative (IMI) consortium IDEA-FAST is developing novel digital measures of fatigue, sleep quality, and impact of sleep disturbances for neurodegenerative diseases and immune-mediated inflammatory diseases. In 2022, the
David Nobbs, Wojciech Piwko, Christopher Bull, Francesca Cormack, Teemu Ahmaniemi, Sebastian C. Holst, Meenakshi Chatterjee, Walter Maetzler, Stefan Avey, Wan Fai Ng   +9 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

DIGITAL EVIDENCE IN CRIMINAL PROCEEDINGS – CHALLENGES AND SOLUTIONS

Pravo
 In the last decade, digital evidence in criminal proceedings has become a key tool in modern forensic investigation, with the help of which it is possible to identify, analyze and verify information that can be crucial for making a decision in court ...
Jelena Matijašević, Nenad Bingulac, Darko Marinković   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Digital evidence and its use for criminal proceedings

Аналітично-порівняльне правознавство
This paper examines the role and admissibility of digital evidence, particularly data derived from instant messaging applications like WhatsApp and Telegram, in criminal proceedings within the legal context of the Slovak Republic.
Jakub Matis
doaj   +1 more source

Perbandingan Tools Forensics pada Fitur TRIM SSD NVMe Menggunakan Metode Live Forensics

IT Journal Research and Development, 2020
SSD saat ini memiliki teknologi media penyimpanan yang baru yaitu Solid State Drive Non-volatile Memory Express (SSD NVMe). Selain itu, SSD memiliki fitur bernama TRIM.
Wisnu Pranoto, Imam Riadi, Yudi Prayudi
doaj   +1 more source

Digital evidence [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2012
Although computer makes human activities faster and easier, innovating and creating new forms of work and other kinds of activities, it also influenced the criminal activity.
Lukić Tatjana
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source