Results 61 to 70 of about 938,555 (258)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Digital forensics and legal communication: network analysis of law enforcement response to viral youth violence cases in Indonesia

Frontiers in Human Dynamics
The viral spread of youth violence content on social media platforms has created unprecedented challenges for law enforcement agencies in Indonesia, requiring rapid response mechanisms that balance digital evidence integrity with public communication ...
Andi Nadia Aryana, Muh. Akbar, Muhammad Farid, Alem Febri Sonni   +3 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Toward Secure and Scalable Digital Evidence Preservation: A Blockchain-Driven Framework

Blockchains
Digital evidence management systems are designed to ensure that the digital evidence is genuine and effectively handle its complexity. In this work, blockchain technology is applied to handle the digital evidence by introducing several layers of security
Areej Dweib, Fadi Abu-Amara, Muath Alrammal   +2 more
doaj   +1 more source

FORENSIC LINGUISTIC EXPERTISE AS A MEANS OF PROTECTING PROPERTY RIGHTS IN THE CONTEXT OF EUROPEAN STANDARDS OF EVIDENCE [PDF]

Alfred Nobel University Journal of Law
The article is devoted to examine the theoretical, methodological, and forensic aspects of using forensic linguistic expertise of speech as a tool for protecting property rights in civil and commercial proceedings.
Аlona V. Bila
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Possibilities for the Implementation of 3D Protocols in the Activities of the Military Law Enforcement Service of the Armed Forces of Ukraine: International Еxperience and Strategies for National Security under Wartime Conditions

Military science
The article is devoted to the development of recommendations on the use of 3D protocols in the activities of the Military Law Enforcement Service in the Armed Forces of Ukraine, taking into account international and Ukrainian experience.
Олександр Гринчук, Володимир Гурковський, Євген Романенко, Андрій Тристан, Роман Захарчук   +4 more
doaj   +1 more source

Admissibility of Digital Evidence at the International Criminal Court [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī
Digital evidence refers to information obtained from both “closed” sources, such as USB flash drives, and “open” sources, like social media posts. This information is produced, stored, received, processed, and transmitted by digital devices.
ziba Nilaei Sangari, Aghil Mohammadi
doaj   +1 more source