Results 81 to 90 of about 2,820,561 (298)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The EBAT architecture: An explainable blockchain for legal AI audits
Ìнформаційні технології та компʼютерна інженеріяThe integration of artificial intelligence into high-stakes domains like the justice system presents the “black box problem”, where algorithmic opacity undermines fundamental legal principles and current blockchain-based auditing solutions fail to bridge
O. Shamov
doaj +1 more source
Digital evidence strategies for digital forensic science examinations
Science & Justice, 2023 Given the size and complexity of many digital forensic science device examinations, there is a need for practitioners to formally and strategically determine a course of conduct which allows them to undertake the most robust and efficient examination possible.
openaire +4 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Communication Privacy Management and Digital Evidence in an Intimate Partner Violence Case
International Journal of Communication, 2019 This article uses a case study of an intimate partner violence criminal case to examine the relationship among communication privacy management, evidence acquisition and retrieval, and the use of digital evidence in criminal court.
Fanny A. Ramirez, Jeffrey Lane
doaj +2 more sources
Certain aspects of criminal evidence and digital evidence
Аналітично-порівняльне правознавствоThe evolution of digital technology has revolutionized the landscape of criminal investigations and legal proceedings. This paper delves into the nuanced realm of evidence, with a particular focus on digital evidence, which has become increasingly ...
Jakub Matis
doaj +1 more source
Digital evidence in Brazil [PDF]
Digital Evidence and Electronic Signature Law Review, 2014 Carlos Alberto Rohrmann and Jason Soares Albergaria Neto set out the position relating to the admission and treatment of digital evidence in Brazil.
Rohrmann, Carlos Alberto +1 more
openaire +1 more source
Beyond competence: digital literacies as knowledge practices, and implications for learner development [PDF]
, 2012 Our interest in studying digital literacies arises from what we perceive as a failure to develop students' capacities to learn deeply in a technology-rich environment. The trends towards networked communities and digital citizenship, as well as workplace
Beetham, Helen +2 more
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source