Results 51 to 60 of about 3,077,379 (274)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Acceptability of artificial intelligence (AI)-enabled chatbots, video consultations and live webchats as online platforms for sexual health advice [PDF]

, 2020
Objectives Sexual and reproductive health (SRH) services are undergoing a digital transformation. This study explored the acceptability of three digital services, (i) video consultations via Skype, (ii) live webchats with a health advisor and (iii ...
Bayley, J., Bayley, J., Graham, C.A., Graham, C.A., Kidsley, S., Kidsley, S., Llewellyn, C., Llewellyn, C., Nadarzynski, T., Nadarzynski, T.   +9 more
core   +1 more source

SONAR, a nursing activity dataset with inertial sensors

Scientific Data, 2023
Accurate and comprehensive nursing documentation is essential to ensure quality patient care. To streamline this process, we present SONAR, a publicly available dataset of nursing activities recorded using inertial sensors in a nursing home.
Orhan Konak, Valentin Döring, Tobias Fiedler, Lucas Liebe, Leander Masopust, Kirill Postnov, Franz Sauerwald, Felix Treykorn, Alexander Wischmann, Stefan Kalabakov, Hristijan Gjoreski, Mitja Luštrek, Bert Arnrich   +12 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The ethics of digital well-being: a multidisciplinary perspective [PDF]

This chapter serves as an introduction to the edited collection of the same name, which includes chapters that explore digital well-being from a range of disciplinary perspectives, including philosophy, psychology, economics, health care, and education ...
A Abukonna, A Alexandrova, A Elder, A Ferretti, A Jobin, A Orben, A Orben, AM Wood, B Fröding, B Goldacre, B Mittelstadt, C Burr, C Burr, C Woodard, CD Ryff, CJ Ferguson, D Hausman, D Howard, D Jeske, D Kahneman, D Lupton, D Parfit, DA Ellis, DB Dwyer, DM Haybron, DM Haybron, E Brynjolfsson, E Diener, E Lin, E Palm, ED Diener, F Greaves, FA Huppert, G Fletcher, I Robeyns, J Garde-Hansen, J Pugh, J Torous, J Williams, JN Craig, JW Galbraith, K Binmore, K Layous, K Sterelny, L Floridi, L Floridi, L Floridi, LK Ma, LW Sumner, M Bishop, M Burke, M Csikszentmihalyi, M Nussbaum, M Themistocleous, MC Nussbaum, MEP Seligman, MR Munafò, MR Munafò, N Kosmyna, NC Manson, NH Frijda, NS Kim, P Henson, P Stokes, P Verduyn, R Challen, R Crisp, R Sharp, R Yost-Dubrow, RA Calvo, RA Calvo, RJ Watson, RM Ryan, RM Ryan, RR Faden, S Allen, S Ghafur, S Leigh, S Sterckx, S Vallor, S Vallor, T Burns, T Hills, T Justinia, TK Mackey, TL Beauchamp, V Tiberius   +86 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

StudyMe: a new mobile app for user-centric N-of-1 trials

Trials, 2022
N-of-1 trials are multi-crossover self-experiments that allow individuals to systematically evaluate the effect of interventions on their personal health goals.
Alexander M. Zenner, Erwin Böttinger, Stefan Konigorski   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Integrating digital Health services : the role of the government and the challenge of cost allocation [PDF]

, 2015
eHealth, mHealth and eCare services are growing in numbers at a fast pace. This is mainly driven by technology and the societal challenges of an aging and more chronically burdened population while pressure on both human and financial resources increases.
Colle, Didier, Vannieuwenborg, Frederic, Verbrugge, Sofie   +2 more
core   +1 more source