Results 141 to 150 of about 3,232,610 (341)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

A fragment-based approach for computing the long-term visual evolution of historical maps

Humanities & Social Sciences Communications
Cartography, as a strategic technology, is a historical marker. Maps are tightly connected to the cultural construction of the environment. The increasing availability of digital collections of historical map images provides an unprecedented opportunity ...
Remi Petitpierre, Johannes H. Uhl, Isabella di Lenardo, Frédéric Kaplan   +3 more
doaj   +1 more source

Knowledge networks in the humanities

, 2014
In settings where digital humanities thrive, there are common ingredients, including strong structures for collaboration, frameworks for interdisciplinary dialogue, spaces for experimentation, and mechanisms for institutionally valuing and sustaining ...
Arthur, Paul Longley (R17536)
core  

Lab and Slack. Situated Research Practices in Digital Humanities Introduction to the DHQ Special Issue

, 2020
Although the concept of digital comes with an assumption of placelessness and detachment from physical space and geographical location, these matters still play a significant role in the way the digital humanities research is practiced today, and also in
Oiva, Mila, Pawlicka-Deger, Urszula
core  

Digital Humanism. The role of the human component in the Digital Humanities

, 2023
Recent trends in scholarship publications, public debate on newspapers, and digital projects in the humanities seem to privilege the quantitative and computational approach to historical studies, as it is considered more objective, and therefore more correct.
openaire   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

No Digital Citizens Without Digital Humanism

, 2023
AbstractUsing a Digital Humanism viewpoint when teaching informatics is the key to face the challenges posed to our society by digital technologies. This is particularly relevant for education in school, where children are going to learn about the basic principles and concepts of the discipline.
openaire   +2 more sources

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Digital Studies of Culture in Central Europe: Introduction to the Thematic Section

Colloquia Humanistica
The idea for this issue of the journal, as well as the earlier project Mapping and Boosting Digital Humanities in the Visegrad Region (led by the NGO Centre of the Study of Popular Culture), stemmed from reflections on the growing dependence of the ...
Robert Kulmiński, Ondřej Daniel
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source