Results 81 to 90 of about 36,964,672 (289)

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Multimodal Lifeworlds: Pedagogies for Play Inquiries and Explorations

Journal of Early Childhood Education Research, 2020
In this paper, we advocate a reconceptualisation of early learning in the 21st century in the form of multimodal lifeworlds. We review the research literature on the role of new technologies for young children’s learning, both in their homes and in ...
Lorna Arnott, Nicola J. Yelland
doaj  

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Developing a Secure Internet-based Network of Trusted Data

Blockchain in Healthcare Today
Our world has not caught up with technology, and as a result has become more dangerous and nefarious with clandestine actors. Learn what reputable organizations, businesses and academic pioneers are doing to preserve digital identity, data provenance ...
Thomas Hardjono, PhD, Florence Hudson, BSE   +1 more
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

That's 'é' not 'þ' '?' or '☐': a user-driven context-aware approach to erroneous metadata in digital libraries [PDF]

, 2011
In this paper we present a novel system for user-driven integration of name variants when interacting with web-based information systems. The growth and diversity of online information means that many users experience disambiguation and collocation ...
Nichols, David M., Bainbridge, David, David M. Nichols, David Bainbridge, Twidale, Michael B., Michael B. Twidale   +5 more
core   +1 more source

Towards a seamless digital Europe: the SSEDIC recommendations on digital identity management

, 2014
The SSEDIC (“Scoping the Single European Digital Identity Community”) thematic network has concluded an intensive 3-year consultation period together with over 200 European and international digital identity management experts and many stakeholder ...
Schunck, Christian, Barchiesi, Maria-Laura, Merella, Daniela, Talamo, Maurizio, Ramachandran, Selvakumar   +4 more
core   +1 more source