Results 81 to 90 of about 370,952 (298)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Identity Service - A future service for collecting, storing, and communicating personal identity, through wearable interfaces [PDF]

open access: yes, 2004
Identity Service is a future service that allows users to store, collect and share Identity related information through wearable digital interfaces while on the move.
Francesca Rosella, Identity Service
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Digital Identity Wallets and their Semantic Contradictions [PDF]

open access: yes, 2023
peer reviewedIn the fight for individual privacy against online surveillance and personal data breaches, blockchain developers often pitch encrypted wallets as solutions.
SMETHURST, Reilly
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Advancing Australia as a digital economy: an update to the national digital economy strategy [PDF]

open access: yes, 2013
The Government’s 2011 National Digital Economy Strategy (the 2011 NDES) set the goal of Australia becoming a leading digital economy by 2020. In doing so, it nominated eight goals to position Australia as a world leader in broadband connectivity and the ...

core  

Digital Identity

open access: yesAnalytical and Comparative Jurisprudence
In modern life, you need to have access to the Internet and register on websites to exercise your rights and responsibilities, order services, perform work and buy goods. Using government offices, banks, healthcare facilities and other services can be more difficult if you do not have access to the Internet. It can also lead to poorer communication and
  +8 more sources

Sharenting in Asunción, Paraguay: Parental Behavior, Risk Perception, and Child Privacy Awareness on Social Media

open access: yesPsychology International
“Sharenting” appears to have become a common practice among families, who tend to normalise the posting of children’s content on social media, which can raise concerns about the privacy, safety, and mental health of exposed children.
María Nieto-Sobrino   +2 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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