Results 61 to 70 of about 370,952 (298)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Towards a holistic approach to policy interoperability in digital libraries and digital repositories [PDF]

, 2011
Underpinning every digital library and digital repository there is a policy framework, which makes the digital library viable - without a policy framework a digital library is little more than a container for content. Policy governs how a digital library
Ashley, Kevin, MacKenzie Smith, Ahley, Kenvin, Pfeiffenberger, Hans, De Robbio, A., Kevin Ashley, Smith, M., Antonella De Robbio, Smith, McKenzie, Ross, Seamus, Faundeen, J., John Faundeen, Seamus Ross, De Robbio, Antonella, Faundeen, John, Ashley, K., Innocenti, P., Pfeiffenberger, H., Ross, S., Robbio, Antonella De, Innocenti, Perla, Perla Innocenti, Smith, MacKenzie, Hans Pfeiffenberger   +23 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Identity Development in Adulthood : Introduction [PDF]

, 2016
In line with Erikson’s suggestions, increasing empirical evidence substantiates that considerable identity development takes place over the course of adulthood. What then does identity development during adulthood entail?
Kroger, Jane, Fadjukoff, Päivi
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Digital Identity

Konfrontasi: Jurnal Kultural, Ekonomi dan Perubahan Sosial, 2020
With the penetration and spread of the Internet in our daily life, issues related to our identity on the Internet and their potential impacts on our lives, whether positive or negative, have become very important. We, as individuals, interact with a number of websites and services on the Internet that require an account (username and password) to ...
null Majeed Mohamed Fareed Majeed, null Abdurahman Adisaputera, null Muhammad Ridwan   +2 more
openaire   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

No Peace After Death? The Impact of AI-Driven Memorial Chatbots on Privacy and Data Protection

Information
This paper examines the profitable digital afterlife industry (DAI), whose aim is to monetize the digital remains of departed internet users. Among the different services offered by such an industry, attention is drawn to AI and humanoid robots that ...
Jacopo Ciani Sciolla, Ugo Pagallo
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

To be or not to be, the importance of Digital Identity in the networked society [PDF]

, 2011
The emergence of the web has had a deep impact at different levels of our society, changing the way people connect, interact, share information, learn and work.
Torres, Ricardo, Costa, Cristina
core