Results 41 to 50 of about 272,038 (253)

Digital Social Identity Management: Current Status, Problems, and Countermeasures

中国工程科学
Currently, China is undergoing a comprehensive transition toward a digital society, which has placed renewed emphasis on the need for robust national-level digital management capabilities.
Yu Rui , Deng Chen, Zhao Yang, Lu Hongbo, Qiu Xuhua, Feng Siqi   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Strategic safeguarding: A game theoretic approach for analyzing attacker-defender behavior in DNN backdoors

EURASIP Journal on Information Security
Deep neural networks (DNNs) are fundamental to modern applications like face recognition and autonomous driving. However, their security is a significant concern due to various integrity risks, such as backdoor attacks.
Kassem Kallas, Quentin Le Roux, Wassim Hamidouche, Teddy Furon   +3 more
doaj   +1 more source

DIGITAL IDENTITY

Scientific Annals of the “Alexandru Ioan Cuza” University, Iaşi. New Series SOCIOLOGY AND SOCIAL WORK Section, 2021
The text aims to bring forward a topical issue, that of digital identity. Based on a series of international  discussions (Davos Forum, EU) but also in the context of recent announcements   in  the  field  of  new  technologies  (the  announcement   made  by  M.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Identity reconstruction and digital addiction: the paradoxical mechanism of digital inclusion among the new generation of older adults

Frontiers in Psychology
IntroductionAgainst the backdrop of population aging and rapid digitalization in China, the new generation of older adults faces a growing paradox of digital inclusion.
Haibei Chen, Xianglian Zhao, Qianjing Zhu   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The issue of digital identity. Properties and risks

Известия высших учебных заведений: Социология. Экономика. Политика
The article is devoted to the study of the phenomenon of digital identity. Based on the analysis, the main approaches to the study of this phenomenon have been summarized, which can be classified according to the degree of comparison of digital identity ...
A. V. Shlyakov
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source