Results 41 to 50 of about 2,277,363 (292)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Identification of asymmetrical abnormalities in functional connectivity and brain network topology for migraine sufferers: A preliminary study based on resting-state fMRI data

Brain Research Bulletin
Research on the neural mechanisms underlying brain asymmetry in patients with migraine patients using fMRI is insufficient. This study proposed using lateralized algorithms for functional connectivity and brain network topology and investigated changes ...
Weifang Nie, Weiming Zeng, Jiajun Yang, Lei Wang, Yuhu Shi   +4 more
doaj   +1 more source

Improving brain tumor segmentation with anatomical prior-informed pre-training

Frontiers in Medicine, 2023
IntroductionPrecise delineation of glioblastoma in multi-parameter magnetic resonance images is pivotal for neurosurgery and subsequent treatment monitoring.
Kang Wang, Kang Wang, Zeyang Li, Haoran Wang, Haoran Wang, Siyu Liu, Siyu Liu, Mingyuan Pan, Manning Wang, Manning Wang, Shuo Wang, Shuo Wang, Zhijian Song, Zhijian Song   +13 more
doaj   +1 more source

A digital high-dynamic-range CMOS image sensor with multi-integration and pixel readout request [PDF]

, 2007
A novel principle has been developed to build an ultra wide dynamic range digital CMOS image sensor. Multiple integrations are used to achieve the required dynamic.
Guilvard, Alexandre, Magnan, Pierre, Martin-Gonthier, Philippe, Segura, Josep   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

DB-Net: A Dual-Branch Hybrid Network for Stroke Lesion Segmentation on Non-Contrast CT Images

IEEE Access
Lesion segmentation in acute ischemic stroke (AIS) is critical for accurate diagnosis, with non-contrast CT (NCCT) serving as the primary imaging modality.
Xiao Jia, He Dong, Jiashu Xu, Yanhong Zhang, Yihua Lan   +4 more
doaj   +1 more source

Digital TV image enhancement system [PDF]

, 1973
Efficient, digital image-enhancement process has been developed for high-resolution slow-scan TV images. Scan converter is no longer subject to registration errors, which become more serious as resolution increases.
Biernson, G. A.
core   +1 more source

Influence of study design on digital pathology image quality evaluation : the need to define a clinical task [PDF]

, 2017
Despite the current rapid advance in technologies for whole slide imaging, there is still no scientific consensus on the recommended methodology for image quality assessment of digital pathology slides.
Ducatelle, Richard, Kumcu, Asli, Philips, Wilfried, Platisa, Ljiljana, Van Brantegem, Leen   +4 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source