Results 111 to 120 of about 8,481 (226)

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Multiaxial Fatigue Behavior of AA6016 and AA6016 to DX54D SPR Joints: Fracture Mechanisms and Data‐Driven Rupp's Model

Fatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT The fatigue and fracture behavior of self‐piercing rivet (SPR) joints between AA6016 aluminum sheets (1–2 mm) and DX54D steel (0.95 mm) was studied under 90°, 45°, and 0° multiaxial loading. Pure shear (90°) loading produced the highest fatigue strength, whereas multiaxial (45°) loading resulted in reduced performance, with pure tension (0 ...
Alan Woo, Amelie Malpot, Behzad Behravesh, Saeid Rezaee, Amirsalar Anousheh, Hamid Jahed   +5 more
wiley   +1 more source

Erythrocyte ‘Feierzeit’ reaction: Novel filamentous and vesicular response to n‐butyl acetate

Journal of Microscopy, EarlyView.
Abstract Human erythrocytes (red blood cells; RBCs) undergo spontaneous disassembly after several hours of exposure to n‐butyl acetate (nBA). Images of the morphological changes were captured in time‐lapse sequences using differential interference contrast (DIC) light microscopy.
Philip W. Kuchel
wiley   +1 more source

Non-contact strain measurement in the mouse forearm loading model using digital image correlation (DIC). [PDF]

Bone, 2015
Begonia MT, Dallas M, Vizcarra B, Liu Y, Johnson ML, Thiagarajan G.   +5 more
europepmc   +1 more source

Axial muscle‐fibre orientations in larval zebrafish

Journal of Anatomy, Volume 246, Issue 4, Page 517-533, April 2025.
In 4 days post‐fertilization zebrafish larvae, the fast axial muscle fibres follow helical trajectories that taper towards the tail. Adjacent muscle fibres form substantial angles relative to each other to accommodate this pattern. Using a novel semi‐automatic method, we quantified 3D fibre angles over the whole muscle volume.
Noraly M. M. E. van Meer, Johan L. van Leeuwen, Henk Schipper, Martin J. Lankheet   +3 more
wiley   +1 more source

Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation

Plant, Cell &Environment, EarlyView.
ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner, Fruzsina Vadai‐Nagy, Magdolna Gombos, Attila Hlacs, Eszter Molnár, Annamária Marton, Csaba Vizler, Rasik Shiekh Bin Hamid, Péter Kaló, Attila Fehér, Zoltán Magyar   +10 more
wiley   +1 more source

The DeepJoint Algorithm: An Innovative Approach for Studying the Longitudinal Evolution of Quantitative Mammographic Density and Its Association With Screen‐Detected Breast Cancer Risk

Biometrical Journal, Volume 68, Issue 3, June 2026.
ABSTRACT High mammographic density is a well‐known risk factor for breast cancer and reduces the sensitivity of mammography‐based screening. While automated machine and deep learning‐based methods provide more consistent and precise measurements compared to subjective Breast Imaging Reporting and Data System (BI‐RADS) assessments, they often fail to ...
Manel Rakez, Julien Guillaumin, Aurelien Chick, Gaelle Coureau, Foucauld Chamming's, Pierre Fillard, Brice Amadeo, Virginie Rondeau   +7 more
wiley   +1 more source

Bayes-DIC Net: Estimating Digital Image Correlation Uncertainty with Bayesian Neural Networks

17 pages, 8 ...
Chen, Biao, Lei, Zhenhua, Zhang, Yahui, Niu, Tongzhi   +3 more
openaire   +2 more sources