Results 51 to 60 of about 2,120,742 (293)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Journal of Theoretical and Applied Electronic Commerce ResearchThe issue of image copyright infringement is prevalent in current e-commerce activities. Users employ methods such as image cropping, compression, and noise addition, making it difficult for traditional copyright detection technologies to identify and ...
Jikuan Xu, Jiamin Zhang, Junhan Wang
doaj +1 more source
Medical image enhancement using threshold decomposition driven adaptive morphological filter [PDF]
, 2008 One of the most common degradations in medical images is their poor contrast quality. This suggests the use of contrast enhancement methods as an attempt to modify the intensity distribution of the image.
Mahmoud, Tarek A., Marshall, Stephen
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Ensuring the discoverability of digital images for social work education : an online tagging survey to test controlled vocabularies [PDF]
, 2009 The digital age has transformed access to all kinds of educational content not only in text-based format but also digital images and other media. As learning technologists and librarians begin to organise these new media into digital collections for ...
Ballantyne, Neil, Daly, Ellen Katherine
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
EviPlant: An efficient digital forensic challenge creation, manipulation and distribution solution
, 2017 Education and training in digital forensics requires a variety of suitable challenge corpora containing realistic features including regular wear-and-tear, background noise, and the actual digital traces to be discovered during investigation.
Du, Xiaoyu, Lillis, David, Scanlon, Mark
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Indian Journal of Dental Research, 2014 Objective: This study aimed to compare digital techniques for evaluating dental enamel de-/remineralization. Materials and Methods: Sixty extracted molars were subjected to a process of de- and remineralization.
Patrícia Leite-Ribeiro +4 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source