Results 101 to 110 of about 2,680,690 (272)

Britain needs a digital inclusion policy with concrete targets for both availability and take-up to counter the emergence of a digital underclass [PDF]

, 2011
Internet use and information technology seems ubiquitous throughout our society – for many, life would be unimaginable without it. But, as Ellen Helsper argues, there is a vast ‘digital underclass’ in the UK that has not benefitted from increasing rates ...
Helsper, Ellen
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Deployment of digital technologies in African cities: emerging issues and policy recommendations for local governments

Data & Policy
The deployment of digital technologies in African cities, beyond improving service delivery, raises issues of digital inclusion, digital rights, and increasing spatial and social inequalities. As part of the African Cities Lab Summit 2023, we conducted a
Leandry Jieutsa, Irina Gbaguidi, Wijdane Nadifi, Shin Koseki   +3 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Digital inclusion UNATI – UNESP/MARÍLIA students

Revista Ciência em Extensão, 2010
Sao Paulo State University (UNESP) created the university extension project called UNATI - Universidade Aberta à Terceira Idade (Open University to Senior Citizen) that offers activities and classes to elderly people with the proposal of making social ...
Silvana Aparecida Borsetti Gregorio Vidotti, Ana Maria Jensen Ferreira da Costa Ferreira, Fernando Luiz Vechiato, Laura Akie Saito Inafuko, Odília Barbosa Ribeiro   +4 more
doaj  

Experiences of Digital Transitions in Health and Social Care Services in Later Life: Findings and Reflections from a Collaborative, Interdisciplinary Exploratory Review

Social Sciences
Health and social care services are increasingly shaped by the emergence of new digital developments. Research suggests that older adults are less likely to use digital devices and, therefore, risk missing out on essential health and social care services
David Alejandro Vaca-Benavides, Sumetha Uthayakumar, Emilie McSwiggan, Kayla Ostrishko, Godfrey Wanok, Clare Halpenny, Elisa Cardamone   +6 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Digital government inclusion: Exploring strategies for inclusive government automation

Government Information Quarterly
The idea of ‘digital government inclusion’ – which builds upon notions of digital and social equity – implies that every person is equally able to participate in and benefit from digital government applications and procedures. In this article, through a policy stages lens, we explore aspects of government automation that complicate various dimensions ...
Peeters, Rik, Miller, Susan M., Schuilenburg, Marc   +2 more
openaire   +2 more sources

Social Digital Series: Digital inclusion and evidence-based policy: Insights from Wales [PDF]

, 2012
Ian Jones, Senior Research Officer for the Welsh Government, discusses findings from research into digital ...
Jones, Ian
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source