Results 101 to 110 of about 2,644,704 (272)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Digital inclusion UNATI – UNESP/MARÍLIA students

Revista Ciência em Extensão, 2010
Sao Paulo State University (UNESP) created the university extension project called UNATI - Universidade Aberta à Terceira Idade (Open University to Senior Citizen) that offers activities and classes to elderly people with the proposal of making social ...
Silvana Aparecida Borsetti Gregorio Vidotti, Ana Maria Jensen Ferreira da Costa Ferreira, Fernando Luiz Vechiato, Laura Akie Saito Inafuko, Odília Barbosa Ribeiro   +4 more
doaj  

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Improving citizen-based monitoring in South Africa: A social media model

African Evaluation Journal
Background: In contemporary public governance, transparent, accountable, and citizen-centric practices are paramount. Citizen-based monitoring (CBM) of government projects is a promising avenue to uphold these principles.
Lesedi S. Matlala
doaj   +1 more source

Digital government inclusion: Exploring strategies for inclusive government automation

Government Information Quarterly
The idea of ‘digital government inclusion’ – which builds upon notions of digital and social equity – implies that every person is equally able to participate in and benefit from digital government applications and procedures. In this article, through a policy stages lens, we explore aspects of government automation that complicate various dimensions ...
Peeters, Rik, Miller, Susan M., Schuilenburg, Marc   +2 more
openaire   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Empowering marginalized communities through the digital transformation course

Frontiers in Education
This article examines a project dedicated to comprehensively addressing the social impact of digital transformation. The project also emphasizes the effects of digital transformation on marginalized populations, especially forced migrants and individuals
Pelin Yüksel-Arslan, Claudia Plant, Fares Kayali   +2 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Young People Learning About Algorithms: Five Profiles Spanning From Ineptitude to Enchantment

Media and Communication
This article focuses on young people’s understanding of algorithms and their learning methods. While many younger individuals are deeply familiar with digital media, it is erroneous to assume that this familiarity is equivalent to operational or critical
Maria José Brites, Teresa Sofia Castro, Mariana S. Müller, Margarida Maneta   +3 more
doaj   +1 more source