Results 81 to 90 of about 8,762 (202)

Exploring inclusion and digital literacy in Latin America as a means for social change: a systematic literature review

Social Sciences and Humanities Open
Digital inclusion has become a priority to achieve a more effective integration of people in the constant transformation processes, in a world dominated by technology.
Enma Sofía Reeves-Huapaya, Haydeé Quispe-Berríos, Leonardo Saravia-Parra, Jaime Renee Chambilla-Baylón, Luis Ronald Rucoba-del Castillo, Judith Elena Vásquez-Dorado, Rolando Oscco-Solorzano, Mario Jaime-Andia   +7 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Digital Transformation in the EU: Bibliometric Analysis and Digital Economy Trends Highlights

Digital
This study highlights the Digital Transformation issues in recent scientific topics, as well as the trends in the European Union’s Digital Economy dynamics.
Dmytro Zherlitsyn, Kostadin Kolarov, Nataliia Rekova   +2 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Deployment of digital technologies in African cities: emerging issues and policy recommendations for local governments

Data & Policy
The deployment of digital technologies in African cities, beyond improving service delivery, raises issues of digital inclusion, digital rights, and increasing spatial and social inequalities. As part of the African Cities Lab Summit 2023, we conducted a
Leandry Jieutsa, Irina Gbaguidi, Wijdane Nadifi, Shin Koseki   +3 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Experiences of Digital Transitions in Health and Social Care Services in Later Life: Findings and Reflections from a Collaborative, Interdisciplinary Exploratory Review

Social Sciences
Health and social care services are increasingly shaped by the emergence of new digital developments. Research suggests that older adults are less likely to use digital devices and, therefore, risk missing out on essential health and social care services
David Alejandro Vaca-Benavides, Sumetha Uthayakumar, Emilie McSwiggan, Kayla Ostrishko, Godfrey Wanok, Clare Halpenny, Elisa Cardamone   +6 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source