Results 51 to 60 of about 139,843 (276)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A situational review of national Digital Health strategy implementation in sub-Saharan Africa

The Journal for Transdisciplinary Research in Southern Africa
As the global communities approach 2030, towards achieving the United Nations (UN) Sustainable Development Goal (SDG) 3 (Good health and well-being), there are commendable technology-driven efforts in sub-Saharan Africa (SSA) to address health care ...
Oluwamayowa O. Ogundaini, Nhlanhla B.W. Mlitwa   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bibliometric Analysis of Digital Leadership Studies

Mehmet Akif Ersoy Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi
The purpose of this study is to provide a comprehensive and holistic perspective on the field of digital leadership by conducting a bibliometric analysis of publications in this field. Web of Science (WoS) Core Collection database was utilized to gateher
Sena Erden Ayhün, İsmail Şimşir, Selma Kılıç Kırılmaz, Erdal Aydın   +3 more
doaj   +1 more source

Leadership in the digital business transformation [PDF]

Proceedings of the 22nd International Academic Mindtrek Conference, 2018
The role of leadership in digital business transformation is a topical issue in need of more in-depth research. Based on an empirical investigation of eight Finnish organizations operating in the service sector, we gain understanding of the role and focus of leadership in the context of digital business transformation.
Riitta-Liisa Larjovuori, Laura Bordi, Kirsi Heikkilä-Tammi   +2 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Digital Leadership: A Systematic Literature Review

The COVID-19 pandemic and digital disruption have transformed the world and organizations on an unprecedented scale, presenting leaders with unique challenges and creating an opportunity to study digital leadership.
Sujey Hernandez Munoz, Dalia, María Olivia Palafox-Soto, Sergio Ochoa-Jiménez, José Carlos López-Figueroa, López-Figueroa, José Carlos, Palafox-Soto, María Olivia, Ochoa-Jiménez, Sergio, Dalia Sujey Hernandez Munoz   +7 more
core   +1 more source

e-Leadership through strategic alignment: an empirical study of small- and medium-sized enterprises in the digital age [PDF]

, 2016
Small- and medium-sized enterprises (SMEs) play an important role in the European economy. A critical challenge faced by SME leaders, as a consequence of the continuing digital technology revolution, is how to optimally align business strategy with ...
O'Regan, Nicholas, Belitski, Maksim, O'Regan, Nicolas, Liu, Kecheng, Li, Weizi, Ghobadian, Abby   +5 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The Role of Economic and Public Finance Tools in Achieving Energy Transition in Europe

Economies
Europe’s decarbonization calls for an increase in the resources used to ensure a fairer transition. The objective of this study is to evaluate the role of public finance in the decarbonization process, considering the context of various uncertainties ...
Alina Cristina Nuta, Rena Huseynova, Florentin Emil Tanasa, Florian Marcel Nuta   +3 more
doaj   +1 more source