Results 71 to 80 of about 831,100 (278)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Using the new positive aspect of digital leadership to improve organizational sustainability: Testing moderated mediation model

Acta Psychologica
In the era of digital transformation, the role of digital leadership in companies is continuously demanded and its importance is increasingly emphasized.
Zian Cheng, Xiu Jin, Won Jun Kwak
doaj   +1 more source

Values-Based Network Leadership in an Interconnected World [PDF]

, 2017
This paper describes values-based network leadership conceptually aligned to systems science, principles of networks, moral and ethical development, and connectivism. Values-based network leadership places importance on a leader\u27s repertoire of skills
Calongne, Cynthia, Hawkins-Scribner, Toni, Sheets, Travis, Stricker, Andrew, Truman, Barbara, Westhauer, Todd   +5 more
core   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

The Role of Digital Leadership in Fostering Innovation: A Study on Digital Organizational Culture as a Mediator in Saudi Higher Education [PDF]

Maǧallaẗ Al-Buḥūṯ Al-Mālīyyaẗ wa Al-Tiğāriyyaẗ
In the era of digital transformation, higher education institutions must develop adaptive strategies to remain competitive and innovative. This study examines the role of digital leadership in fostering organizational innovation, with a particular focus ...
Wejdan Alasqah, Amr Noureldin
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

DETERMINANT FACTORS ASSOCIATED WITH DIGITALIZATION OF LEADERSHIP COMMUNICATION AT HOSPITAL

Nurse and Health
Background: The digital era has accelerated the digitalization of organizational processes, including leadership communication. The emergence of digital leadership requires leaders to adapt their communication and leadership styles to dynamic ...
Ni Luh Putu Inca Buntari Agustini, Dewa Gede Wisnu Wardana, I Gusti Ngurah Made Gusti Kusuma Negara, Yustina Ni Putu Yusniawati, Israfil Israfil, I Gede Putu Darma Suyasa   +5 more
doaj   +1 more source

A 10-Point Agenda for Comprehensive Telecom Reform [PDF]

, 2001
Changing committee chairmanships in Congress and a leadership shakeup at the Federal Communications Commission have once again opened a window of opportunity for comprehensive telecommunications policy reform.
Adam D. Thierer
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Teachers' perceptions of principals’ digital leadership practices in a school district in a developing country

Social Sciences and Humanities Open
The fourth industrial revolution's (4IR's) disruptive digital technologies and innovations are radically altering the educational environment. The aim and structure of schooling have become progressively digital and different from the norm. Understanding
Judy Dasruth, Suraiya Rathankoomar Naicker, Clive Smith   +2 more
doaj   +1 more source