Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu +13 more
wiley +1 more source
Navigating online health information: empowerment vs. misinformation. [PDF]
Silburn A.
europepmc +1 more source
Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan +14 more
wiley +1 more source
The coupling coordination relationship and obstacle factors of public cultural services and economic development: A case study of 31 regions in China. [PDF]
Xu B, Gu Z, Wang Z, Chen Y, Wang Y.
europepmc +1 more source
Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang +25 more
wiley +1 more source
Enhancing book genre classification with BERT and InceptionV3: a deep learning approach for libraries. [PDF]
Yang X, Zhang Z.
europepmc +1 more source
Effect of the scan body alignment process on the accuracy of virtual definitive implant casts: a pilot study. [PDF]
Pérez JO +3 more
europepmc +1 more source
In-matrix library preparation for metagenomic sequencing of microbial cell-free DNA. [PDF]
Babb PL +10 more
europepmc +1 more source
Strategies for engaging "hard-to-reach" populations in a panel for digital health research: A qualitative study among experts. [PDF]
Oldhoff-Nuijsink C +3 more
europepmc +1 more source

