Results 61 to 70 of about 2,842,826 (284)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Digital, material and networked: some emerging themes for SET education [PDF]
, 2015 Boundaries between the digital and material worlds are becoming blurred as the internet increasingly connects us to things as well as people and information.
Davies, Sarah-Jane +2 more
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
The Transformation of Literary Genres in the Digital Age
Філологічні студіїThis article examines the in-depth evolution of literary genres in the digital age, focusing on the impact of digital technologies, hypertextuality, social media platforms, and interactive media on traditional literary forms. The twenty-first century has
Oksana Melnyk +2 more
doaj +1 more source
Digital Barriers in Digital Transition and Digital Transformation: Literature Review
Economics and Culture, 2023 Abstract Research purpose. The research aimed to identify digital barriers in the digital transition and digital transformation in businesses and industries under the umbrella of human resource management. The topicality of the research relates to the need to identify digital barriers impeding digital transition and ...
Kristine Uzule, Natalija Verina
openaire +2 more sources
DNA barcoding and taxonomy: dark taxa and dark texts [PDF]
, 2016 Both classical taxonomy and DNA barcoding are engaged in the task of digitizing the living world. Much of the taxonomic literature remains undigitized. The rise of open access publishing this century and the freeing of older literature from the shackles ...
Page, Roderic D.M.
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Preserving Open Access Journals: A Literature Review [PDF]
, 2010 This literature review addresses certain questions concerning the preservation of free, born-digital scholarly materials. It covers recent thinking on the current state of preservation efforts of born-digital materials; the range of actors involved in ...
Jottkandt, Sigi
core
Construction safety and digital design: a review [PDF]
, 2012 As digital technologies become widely used in designing buildings and infrastructure, questions arise about their impacts on construction safety. This review explores relationships between construction safety and digital design practices with the aim ...
Sacks, Rafael +2 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source