Results 31 to 40 of about 485,952 (259)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multichannel Residual Conditional GAN-Leveraged Abdominal Pseudo-CT Generation via Dixon MR Images

open access: yesIEEE Access, 2019
Magnetic resonance (MR) images have distinctive advantages in radiation treatment (RT) planning due to their superior, anatomic and functional information compared with computed tomography (CT).
Ke Xu   +7 more
doaj   +1 more source

Successful learning with whiteboard animations – A question of their procedural character or narrative embedding?

open access: yesHeliyon, 2023
Although whiteboard animations are increasingly used for educational purposes, there is little empirical evidence as to why such animations can enhance learning. To specify essential elements, their dynamic visual presentation, as well as their narrative
Sascha Schneider   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

“This Is Shared Work:” Negotiating Boundaries in a Social Service Intermediary Organization

open access: yesMedia and Communication, 2019
This article discusses the results from our fieldwork at a social service intermediary organization working to reform criminal justice institutions in a large city in the American South.
Mariam Asad, Christopher A. Le Dantec
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

A content‐dependent Daltonization algorithm for colour vision deficiencies based on lightness and chroma information

open access: yesIET Image Processing, 2021
To help CVD (colour vision deficiency) observers distinguish among different colours in digital images, this study proposes a content‐dependent Daltonization algorithm based on lightness and chroma information.
Xuming Shen, Jianhua Feng, Xiandou Zhang
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Microstructure and magnetic properties of ultrathin FePt granular films

open access: yesAIP Advances, 2018
FePt granular films with grain size smaller than 10 nm are promising candidates for storage media used in the next generation heat-assisted magnetic recording technology.
Yuepeng Zhang   +15 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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