Results 41 to 50 of about 434,724 (262)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Topic Diversity in Social Media Campaigning: A Study of the 2022 Australian Federal Election
Politics and GovernanceThis study explores the diversity of topics in political campaign communication on social media during the 2022 Australian federal election. While political campaigns on social media are often associated with both persuasive and mobilising appeals, this ...
Hannah Decker +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
DeepStar: Detecting Starring Characters in Movies
IEEE Access, 2019 Recent advances in the film industry have given rise to exponential growth in movie/drama production and adaptation of the Big Data concept. Automatic identification and classification of movie characters have received tremendous attention from ...
Ijaz Ul Haq +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Research of Neural Style Transfer on Line Structure Based on Sequence to Sequence Learning
IEEE Access, 2020 It has always been a challenge for drawing novices to start learning from a zero proficiency level, oftentimes the process itself can discourage them from continuing.
Wei He, Lifang Chen
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
La Formación Archivística en San Luís Potosí. Reflejo de una necesidad nacional
Documentación de las Ciencias de la Información, 2012 Este trabajo presenta, de manera general, el desarrollo de la archivística hasta alcanzar su estamento de ciencia y, por otra parte, la influencia del quehacer organizativo de los documentos existentes y su tratamiento como una ciencia y la formación de ...
Guadalupe Patricia Ramos Fandiño +1 more
doaj
Cognitive Research, 2018 Schema acquisition processes comprise an essential source of cognitive demands in learning situations. To shed light on related mechanisms and influencing factors, this study applied a continuous multi-measure approach for cognitive load assessment. In a
Maria Wirzberger +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source