Results 61 to 70 of about 5,928,293 (297)
Microstructure and magnetic properties of ultrathin FePt granular films
AIP Advances, 2018 FePt granular films with grain size smaller than 10 nm are promising candidates for storage media used in the next generation heat-assisted magnetic recording technology.
Yuepeng Zhang +15 more
doaj +1 more source
Frontiers in Psychology, 2022 Several studies highlight the importance of the order of different instructional methods when designing learning environments. Correct but also erroneous worked examples are frequently used methods to foster students’ learning performance, especially in ...
Lukas Wesenberg +5 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Topic Diversity in Social Media Campaigning: A Study of the 2022 Australian Federal Election
Politics and GovernanceThis study explores the diversity of topics in political campaign communication on social media during the 2022 Australian federal election. While political campaigns on social media are often associated with both persuasive and mobilising appeals, this ...
Hannah Decker +6 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
DeepStar: Detecting Starring Characters in Movies
IEEE Access, 2019 Recent advances in the film industry have given rise to exponential growth in movie/drama production and adaptation of the Big Data concept. Automatic identification and classification of movie characters have received tremendous attention from ...
Ijaz Ul Haq +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A Research of Neural Style Transfer on Line Structure Based on Sequence to Sequence Learning
IEEE Access, 2020 It has always been a challenge for drawing novices to start learning from a zero proficiency level, oftentimes the process itself can discourage them from continuing.
Wei He, Lifang Chen
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
La Formación Archivística en San Luís Potosí. Reflejo de una necesidad nacional
Documentación de las Ciencias de la Información, 2012 Este trabajo presenta, de manera general, el desarrollo de la archivística hasta alcanzar su estamento de ciencia y, por otra parte, la influencia del quehacer organizativo de los documentos existentes y su tratamiento como una ciencia y la formación de ...
Guadalupe Patricia Ramos Fandiño +1 more
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