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Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics.

Lab Chip
Naquin T, Naquin C, Wu Q, Chen Y, Canning A, Yang K, Li Y, Zhao S, Ling Y, Ma Z, Jin K, He Y, Yang S, Lee LP, Huang TJ.   +14 more
europepmc   +1 more source

Digital Manufacturing for Microfluidics

Annual Review of Biomedical Engineering, 2019
The microfluidics field is at a critical crossroads. The vast majority of microfluidic devices are presently manufactured using micromolding processes that work very well for a reduced set of biocompatible materials, but the time, cost, and design constraints of micromolding hinder the commercialization of many devices.
Nirveek Bhattacharjee, Albert Folch
exaly   +4 more sources

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Digital Microfluidics

Annual Review of Analytical Chemistry, 2012
Digital microfluidics (DMF) is an emerging liquid-handling technology that enables individual control over droplets on an open array of electrodes. These picoliter- to microliter-sized droplets, each serving as an isolated vessel for chemical processes, can be made to move, merge, split, and dispense from reservoirs.
Kihwan, Choi, Alphonsus H C, Ng, Ryan, Fobel, Aaron R, Wheeler   +3 more
openaire   +3 more sources

Paper Microfluidics Goes Digital

Advanced Materials, 2014
The first example of so-called "digital microfluidics" (DMF) implemented on paper by inkjet printing is reported. A sandwich enzyme-linked immunosorbent assay (ELISA) is demonstrated as an example of a complex, multistep protocol that would be difficult to achieve with capillary-driven paper microfluidics.
Ryan Fobel, Alphonsus H C Ng, Aaron R Wheeler   +2 more
exaly   +3 more sources

Digital Microfluidics for Immunoprecipitation

Analytical Chemistry, 2016
Immunoprecipitation (IP) is a common method for isolating a targeted protein from a complex sample such as blood, serum, or cell lysate. In particular, IP is often used as the primary means of target purification for the analysis by mass spectrometry of novel biologically derived pharmaceuticals, with particular utility for the identification of ...
Brendon, Seale, Charis, Lam, Darius G, Rackus, M Dean, Chamberlain, Chang, Liu, Aaron R, Wheeler   +5 more
openaire   +2 more sources

Digital microfluidic meter-on-chip

Lab on a Chip, 2020
On-chip digital microfluidic flowmetry can be designed and incorporated into standard microfluidic devices for high-precision multiplexed microflow measurements.
Zecong Fang, Yi Ding, Zhichao Zhang, Fei Wang, Zuankai Wang, Hao Wang, Tingrui Pan   +6 more
openaire   +2 more sources

Digital microfluidics for biological analysis and applications

Lab on a Chip, 2023
Digital microfluidic (DMF) bioassays with the benefits of automation, addressability, integration and dynamic configuration ability for nucleic acids, proteins, immunoreaction and cell analysis are presented in this review.
Xing Xu, Linfeng Cai, Shanshan Liang, Qiannan Zhang, Shiyan Lin, Mingying Li, Qizheng Yang, Chong Li, Ziyan Han, Chaoyong Yang   +9 more
openaire   +2 more sources

Velocity Saturation in Digital Microfluidics

Langmuir, 2019
In digital microfluidics, discrete droplets of fluid are made to move on an open surface with no microchannels. These systems are commonly operated by application of electrical driving forces to an array of electrodes. While these driving forces are well characterized, the dissipative forces opposing droplet movement have not been as thoroughly ...
Ian Swyer, Ryan Fobel, Aaron R. Wheeler
openaire   +2 more sources

Additive-Free Digital Microfluidics

Langmuir, 2013
Digital microfluidics, a technique for manipulation of droplets, is becoming increasingly important for the development of miniaturized platforms for laboratory processes. Despite the enthusiasm, droplet motion is frequently hindered by the desorption of proteins or other analytes to surfaces.
Sergio L S, Freire, Brendan, Tanner
openaire   +2 more sources