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Digital Microfluidic Cell Culture
Annual Review of Biomedical Engineering, 2015Digital microfluidics (DMF) is a droplet-based liquid-handling technology that has recently become popular for cell culture and analysis. In DMF, picoliter- to microliter-sized droplets are manipulated on a planar surface using electric fields, thus enabling software-reconfigurable operations on individual droplets, such as move, merge, split, and ...
Alphonsus H C, Ng +3 more
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A digital microfluidic electrochemical immunoassay
Lab Chip, 2014Digital microfluidics (DMF) has emerged as a popular format for implementing quantitative immunoassays for diagnostic biomarkers. All previous reports of such assays have relied on optical detection; here, we introduce the first digital microfluidic immunoassay relying on electrochemical detection.
Mohtashim H, Shamsi +3 more
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Machine vision for digital microfluidics
Review of Scientific Instruments, 2010Machine vision is widely used in an industrial environment today. It can perform various tasks, such as inspecting and controlling production processes, that may require humanlike intelligence. The importance of imaging technology for biological research or medical diagnosis is greater than ever.
Yong-Jun, Shin, Jeong-Bong, Lee
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2014
Electromechanically driven fluid displacement over solid surfaces has significant advantages over bulk flow regimes, particularly when the fluid volume is in the form of a droplet. Voltage-induced interfacial surface tension alterations at the unbound surface of a droplet increase the droplets' wettability over a hydrophobic surface. This phenomenon is
Kailiang Wang, Henry O. Fatoyinbo
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Electromechanically driven fluid displacement over solid surfaces has significant advantages over bulk flow regimes, particularly when the fluid volume is in the form of a droplet. Voltage-induced interfacial surface tension alterations at the unbound surface of a droplet increase the droplets' wettability over a hydrophobic surface. This phenomenon is
Kailiang Wang, Henry O. Fatoyinbo
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Perspectives on digital microfluidics
Sensors and Actuators A: Physical, 2016Abstract Digital microfluidics (DMF) is a technique for manipulation of discrete droplets on a substrate, which allows timed motion of fluids, with accurate control, representing an alternative to steer away from the conventional paradigm of transporting fluids in enclosed channels.
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Democratizing Digital Microfluidics
2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), 2021As a subset of microfluidics, digital microfluidics handles fluids as small discrete entities (e.g., droplets) by actuating them individually. The choice of actuation mechanism to handle droplets has been electrowetting, especially in the form of electrowetting-on-dielectric (EWOD) developed in early 2000s.
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Digital Microfluidic Logic Gates
2009Microfluidic computing is an emerging application for microfluidics technology. We propose microfluidic logic gates based on digital microfluidics. Using the principle of electrowetting-on-dielectric, AND, OR, NOT and XOR gates are implemented through basic droplet-handling operations such as transporting, merging and splitting.
Yang Zhao 0001 +2 more
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Digital microfluidics on a wire
Applied Physics Letters, 2009In this letter, we discuss the behavior of droplets on fiber networks. An on/off transition is observed when a droplet comes around an intersection between several fibers: large droplets cross the junction while small droplets remain pinned. We show that fibers perform advantageously most operations of digital microfluidics, such as multiplexed ...
Gilet, Tristan +2 more
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Proceedings of the seventh IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis, 2011
Microfluidic biochips are replacing the conventional biochemical analyzers, and are able to integrate on-chip all the basic functions for biochemical analysis. The “digital” microfluidic biochips (DM-FBs) are manipulating liquids not as a continuous flow, but as discrete droplets on a two-dimensional array of electrodes. Basic mi-crofluidic operations,
Tsung-Yi Ho +2 more
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Microfluidic biochips are replacing the conventional biochemical analyzers, and are able to integrate on-chip all the basic functions for biochemical analysis. The “digital” microfluidic biochips (DM-FBs) are manipulating liquids not as a continuous flow, but as discrete droplets on a two-dimensional array of electrodes. Basic mi-crofluidic operations,
Tsung-Yi Ho +2 more
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Design-for-Testability for Digital Microfluidic Biochips
2009 27th IEEE VLSI Test Symposium, 2009Testing is essential for digital microfluidic biochips that are used for safety-critical applications such as point-of-care health assessment, air-quality monitoring, and food-safety testing. However, the effectiveness of recently proposed test techniques for biochips is limited by the fact that current design methods do not consider testability.
Tao Xu 0002, Krishnendu Chakrabarty
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