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Antifouling Properties of Pluronic and Tetronic Surfactants in Digital Microfluidics.

ACS Applied Materials and Interfaces, 2023
Fouling at liquid-solid interfaces is a pernicious problem for a wide range of applications, including those that are implemented by digital microfluidics (DMF).
Man Ho   +7 more
semanticscholar   +1 more source

Digital-scRRBS: A Cost-Effective, Highly Sensitive, and Automated Single-Cell Methylome Analysis Platform via Digital Microfluidics.

Analytical Chemistry, 2023
Single-cell DNA methylation sequencing is highly effective for identifying cell subpopulations and constructing epigenetic regulatory networks. Existing methylome analyses require extensive starting materials and are costly, complex, and susceptible to ...
Xi Zeng   +8 more
semanticscholar   +1 more source

Robotic digital microfluidics: a droplet-based total analysis system.

Lab on a Chip, 2023
Developing automated platforms for point-of-need testing is a crucial global demand. Digital microfluidics is a promising solution for expanding integrated testing devices featuring ultimate control over the chemical and biological reactions in micro ...
M. J. Kiani   +5 more
semanticscholar   +1 more source

Thin-film-transistor digital microfluidics for high value in vitro diagnostics at the point of need.

Lab on a Chip, 2021
The latest developments in thin-film-transistor digital-microfluidics (TFT-DMF, also known by the commercial name aQdrop™) are reported, and proof of concept application to molecular diagnostics (e.g.
Sally Anderson, B. Hadwen, C. Brown
semanticscholar   +1 more source

On-the-Fly Mass Spectrometry in Digital Microfluidics Enabled by a Microspray Hole: Toward Multidimensional Reaction Monitoring in Automated Synthesis Platforms.

Journal of the American Chemical Society, 2022
We report an approach for the online coupling of digital microfluidics (DMF) with mass spectrometry (MS) using a chip-integrated microspray hole (μSH). The technique uses an adapted electrostatic spray ionization (ESTASI) method to spray a portion of a ...
A. Das   +10 more
semanticscholar   +1 more source

Integrating machine learning and digital microfluidics for screening experimental conditions.

Lab on a Chip, 2022
Digital microfluidics (DMF) has the signatures of an ideal liquid handling platform - as shown through almost two decades of automated biological and chemical assays.
Fatemeh Ahmadi   +7 more
semanticscholar   +1 more source

Surface-Enhanced Raman Spectroscopic Probing in Digital Microfluidics through a Microspray Hole.

Analytical Chemistry, 2022
We report a novel approach for surface-enhanced Raman spectroscopy (SERS) detection in digital microfluidics (DMF). This is made possible by a microspray hole (μSH) that uses an electrostatic spray (ESTAS) for sample transfer from inside the chip to an ...
A. Das   +4 more
semanticscholar   +1 more source

"One-to-three" droplet generation in digital microfluidics for parallel chemiluminescence immunoassays.

Lab on a Chip, 2021
In digital microfluidics, droplet generation is a fundamental operation for quantitative liquid manipulation. The generation of well-defined micro-droplets on a chip with restricted device geometries has become a real obstacle for digital microfluidics ...
K. Jin   +5 more
semanticscholar   +1 more source

Sensitive, Rapid, and Automated Detection of DNA Methylation Based on Digital Microfluidics.

ACS Applied Materials and Interfaces, 2021
Biomarkers based on DNA methylation have attracted wide attention in biomedical research due to their potential clinical value. Therefore, a sensitive and accurate method for DNA methylation detection is highly desirable for the discovery and diagnostics
Qingyu Ruan   +10 more
semanticscholar   +1 more source

Cancer drug screening with an on-chip multi-drug dispenser in digital microfluidics.

Lab on a Chip, 2021
Microfluidics has been the most promising platform for drug screening with a limited number of cells. However, convenient on-chip preparation of a wide range of drug concentrations remains a large challenge and has restricted wide acceptance of ...
Jiao Zhai   +9 more
semanticscholar   +1 more source

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