Results 31 to 40 of about 16,038 (246)

Hydrogel discs for digital microfluidics [PDF]

Biomicrofluidics, 2012
Hydrogels are networks of hydrophilic polymer chains that are swollen with water, and they are useful for a wide range of applications because they provide stable niches for immobilizing proteins and cells. We report here the marriage of hydrogels with digital microfluidic devices.
Lindsey K, Fiddes, Vivienne N, Luk, Sam H, Au, Alphonsus H C, Ng, Victoria, Luk, Eugenia, Kumacheva, Aaron R, Wheeler   +6 more
openaire   +2 more sources

Newborn Screening for Fabry Disease: Current Status of Knowledge

International Journal of Neonatal Screening, 2023
Fabry disease is an X-linked progressive lysosomal disorder, due to α-galactosidase A deficiency. Patients with a classic phenotype usually present in childhood as a multisystemic disease.
Vincenza Gragnaniello, Alessandro P. Burlina, Anna Commone, Daniela Gueraldi, Andrea Puma, Elena Porcù, Maria Stornaiuolo, Chiara Cazzorla, Alberto B. Burlina   +8 more
doaj   +1 more source

Amorphous silicon photosensors integrated in microfluidic structures as a technological demonstrator of a “true” Lab-on-Chip system

Sensing and Bio-Sensing Research, 2015
In this paper we present a compact technological demonstrator including on the same glass substrate an electrowetting-on-dielectrics (EWOD) system, a linear array of amorphous silicon photosensor and a capillary-driven microfluidic channel.
Domenico Caputo, Annalisa de Angelis, Nicola Lovecchio, Augusto Nascetti, Riccardo Scipinotti, Giampiero de Cesare   +5 more
doaj   +1 more source

Microdroplet splitting and mixing by portable triboelectric nanogenerator

Nano Research
The advancement of digital microfluidics technology has been pivotal in academic research and engineering applications. However, the prevailing limitation is that traditional voltage sources generate an excess of Joule heat, adversely impacting droplet ...
Qi Gao, Qin Xiang, Wenkai Liu, Mengru Ding, Wei Long, Jianlong Wang, Xiaojun Cheng, Hengyu Li, Zhong Lin Wang, Tinghai Cheng   +9 more
doaj   +1 more source

Single-nucleotide polymorphism detection based on an active-matrix digital microfluidics pyrosequencing lab-on-a-chip platform [PDF]

Sensors & Diagnostics
Single-nucleotide polymorphisms (SNPs), as the most prevalent form of single-base variations within the genome, play a critical role in modulating protein function, regulating gene expression, and determining individual disease susceptibility, thereby ...
Huiting Hu, Tong Wang, Bingbing Zhang, Kai Jin, Zihan Wang, Qi Huang, Hanbin Ma, Jinhua Li, Zhiyao Chen, Siyi Hu   +9 more
doaj   +1 more source

Recent advancements in single-cell metabolic analysis for pharmacological research

Journal of Pharmaceutical Analysis, 2023
Cellular heterogeneity is crucial for understanding tissue biology and disease pathophysiology. Pharmacological research is being advanced by single-cell metabolic analysis, which offers a technique to identify variations in RNA, proteins, metabolites ...
Ying Hou, Hongren Yao, Jin-Ming Lin
doaj   +1 more source

3D Printed Flowmeter Based on Venturi Effect with Integrated Pressure Sensors

Proceedings, 2018
In this paper we present a 3D printed flow meter based on venturri effect. Dimensions of the microchannels are 800 µm for wider and 400 µm for thinker channel.
Krzysztof Adamski, Bartosz Kawa, Rafał Walczak   +2 more
doaj   +1 more source

Dynamic Contact Angle Variation with Applied Voltage and Droplet Volume in Digital Microfluidics

Engineering Proceedings, 2023
Digital microfluidics allows for controlled droplet movement by applying AC or DC voltages. In this research, we investigated the dynamic contact angle variation of droplets at different voltages and droplet volumes in a digital microfluidics platform ...
Moazzam Ali, Hammas Ullah, Mubashar Ali, Nauman Naeem, Hamza Abbas, Ali Turab Jafry   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source