Results 61 to 70 of about 2,871,670 (306)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Development of a 3D printer using scanning projection stereolithography [PDF]

, 2015
We have developed a system for the rapid fabrication of low cost 3D devices and systems in the laboratory with micro-scale features yet cm-scale objects.
Cooper, Geoffrey J.T., Cronin, Leroy, Gibson, Graham M., Hinkley, Trevor, Lee, Michael P., Padgett, Miles J.   +5 more
core   +1 more source

Micropatterned Biphasic Printed Electrodes for High‐Fidelity on‐Skin Bioelectronics

Advanced Functional Materials, EarlyView.
Micropatterned biphasic printed electrodes achieve unprecedented skin conformity and low impedance by combining liquid‐metal droplets with microstructured 3D lattices. This scalable approach enables high‐fidelity detection of ECG, EMG, and EEG signals, including alpha rhythms from the forehead, with long‐term comfort and stability.
Manuel Reis Carneiro, Telmo Lopes, André F. Silva, Carmel Majidi, Mahmoud Tavakoli   +4 more
wiley   +1 more source

Influence of Inclined Chip Angles on Dynamic Contact Angle Variations in Digital Microfluidics [PDF]

MATEC Web of Conferences
The impact of tilted angles on contact angles of water droplets in digital microfluidics was investigated. Experiments were conducted tilting the chip from 0 to 10 degrees at voltage increments of 50V from 250V to 400V DC.
Ali Moazzam, Ullah Hammas, Javaid Hamza, Naeem Nauman, Jafry Ali Turab, Ajab Huma   +5 more
doaj   +1 more source

BioScript: programming safe chemistry on laboratories-on-a-chip [PDF]

, 2018
This paper introduces BioScript, a domain-specific language (DSL) for programmable biochemistry which executes on emerging microfluidic platforms. The goal of this research is to provide a simple, intuitive, and type-safe DSL that is accessible to life ...
Brisk, Philip, Curtis, Chris, Lesani, Mohsen, Loveless, Tyson, Ott, Jason   +4 more
core  

Endovascular Embolization by Transcatheter Delivery of Particles: Past, Present, and Future. [PDF]

, 2017
Minimally invasive techniques to occlude flow within blood vessels, initially pioneered in the 1970s with autologous materials and subsequently advanced with increasingly sophisticated engineered biomaterials, are routinely performed for a variety of ...
Avery, Reginald K, Khademhosseini, Ali, Krishnamurthy, Savitri, Oklu, Rahmi, Sabir, Sharjeel, Sheth, Rahul A, Zhang, Yu Shrike   +6 more
core   +2 more sources

Harnessing Non‐Covalent Protein–Protein Interaction Domains for Production of Biocatalytic Materials Systems

Advanced Functional Materials, EarlyView.
Non‐covalent protein–protein interactions mediated by SH3, PDZ, or GBD domains enable the self‐assembly of stable and biocatalytically active hydrogel materials. These soft materials can be processed into monodisperse foams that, once dried, exhibit enhanced mechanical stability and activity and are easily integrated into microstructured flow ...
Julian S. Hertel, Maria Alessandra Martini, Marius Stoeckle, Annika J. Weber, Kersten S. Rabe, Christof M. Niemeyer   +5 more
wiley   +1 more source

Syndromic surveillance and pathogen detection using multiplex assays for respiratory infections in small ruminants [PDF]

, 2018
Background Several bacterial and viruses can infect the respiratory tract of small ruminants causing similar clinical signs. The differential diagnosis of respiratory diseases in small ruminants can be achieved using multi-plex assays for an accurate ...
Cattoli, Giovanni, Diallo, Adama, Euloge Lamien, Charles, Loitsch, Angelika, Settypalli, Tirumala Bharani Kumar, Tounkara, Kadidia   +5 more
core  

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

Advanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang, Gwendoline A. E. Anand, Rubaiyet Haque, Dylan A. Chiaro, Mona Sharma, Andrew R. Williams, Frank Niklaus, Daryl W. Yee, Gavin M. King, Anpan Han   +9 more
wiley   +1 more source

Droplet-Based Microfluidics with Mass Spectrometry for Microproteomics

Engineering
Microproteomics, the profiling of protein expressions in small cell populations or individual cells, is essential for understanding complex biological systems.
Hang Li, Yudan Ma, Rongxin Fu, Jiaxi Peng, Yanbing Zhai, Jinhua Li, Wei Xu, Siyi Hu, Hanbin Ma, Aaron R. Wheeler, Shuailong Zhang   +10 more
doaj   +1 more source