Results 61 to 70 of about 17,520 (245)

Digital microfluidic immunocytochemistry in single cells [PDF]

Nature Communications, 2015
AbstractWe report a new technique called Digital microfluidic Immunocytochemistry in Single Cells (DISC). DISC automates protocols for cell culture, stimulation and immunocytochemistry, enabling the interrogation of protein phosphorylation on pulsing with stimulus for as little as 3 s.
Ng, Alphonsus H. C., Chamberlain, M. Dean, Situ, Haozhong, Lee, Victor, Wheeler, Aaron R.   +4 more
openaire   +2 more sources

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Droplet-based lab-on-chip platform integrated with laser ablated graphene heaters to synthesize gold nanoparticles for electrochemical sensing and fuel cell applications

Scientific Reports, 2021
Controlled, stable and uniform temperature environment with quick response are crucial needs for many lab-on-chip (LOC) applications requiring thermal management.
Sangam Srikanth, Sohan Dudala, U. S. Jayapiriya, J. Murali Mohan, Sushil Raut, Satish Kumar Dubey, Idaku Ishii, Arshad Javed, Sanket Goel   +8 more
doaj   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Single-Sided Digital Microfluidic (SDMF) Devices for Effective Coolant Delivery and Enhanced Two-Phase Cooling

Micromachines, 2016
Digital microfluidics (DMF) driven by electrowetting-on-dielectric (EWOD) has recently been attracting great attention as an effective liquid-handling platform for on-chip cooling.
Sung-Yong Park, Youngsuk Nam
doaj   +1 more source

A digital microfluidic biochip synthesis framework

2012 IEEE/IFIP 20th International Conference on VLSI and System-on-Chip (VLSI-SoC), 2012
Synthesis of digital microfluidic biochips (DMFBs) is a crucial to the advancement and realization of miniaturized, automated, programmable biochemistry solutions; synthesis is performed in three steps: scheduling, placement and routing. In principle, algorithms for specific steps should be interchangeable with one another; however, different research ...
Daniel T. Grissom, Kenneth O'Neal, Benjamin Preciado, Hiral Patel, Robert Doherty, Nick Liao, Philip Brisk   +6 more
openaire   +4 more sources

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity

Advanced Healthcare Materials, EarlyView.
This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri   +10 more
wiley   +1 more source

Silicone oil–based ferrofluid microrobots for versatile magnetic digital microfluidics

Droplet
Magnetic digital microfluidics offers a promising alternative to the dominant electrowetting‐based digital microfluidics but faces significant challenges regarding system portability, sample contamination, and limited functionality.
Pu Liu, Leilei Chen, Yulei Fu, Wendong Wang   +3 more
doaj   +1 more source

Label-Free Sensing in Microdroplet-Based Microfluidic Systems

Chemosensors, 2018
Droplet microfluidic systems have evolved as fluidic platforms that use much less sample volume and provide high throughput for biochemical analysis compared to conventional microfluidic devices.
Ali Kalantarifard, Abtin Saateh, Caglar Elbuken   +2 more
doaj   +1 more source

Miniaturized Continuous-Flow Digital PCR for Clinical-Level Serum Sample Based on the 3D Microfluidics and CMOS Imaging Device

Sensors, 2020
In recent years, the development of polymerase chain reaction (PCR) technology has focused on digital PCR, which depends on the microfluidics. Based on continuous-flow microfluidic technology, this paper designed a miniaturized digital PCR amplification ...
Bin Li, Yuanming Li, Andreas Manz, Wenming Wu   +3 more
doaj   +1 more source