Results 51 to 60 of about 36,272,883 (300)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Resources, 2020 The variable nature of the coalmine roof poses a challenge to roadway stability during underground coal mining. There have been fatalities and financial losses in the coal mining industry due to roadway failures and roof falls.
Manoj Khanal +3 more
doaj +1 more source
Digital Capitalism and Coal Mine Workers
tripleC: Communication, Capitalism & Critique. Open Access Journal for a Global Sustainable Information Society, 2020 One hundred and seventy-five years ago, in his book titled The Condition of the Working Class in England, Engels wrote about the ways in which the mine workers were exploited within the capitalist system. Classical economists believed that with the improvements in technology, capitalism would create egalitarian employment opportunities for everyone. In
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Mining a digital library for influential authors
Proceedings of the 7th ACM/IEEE-CS joint conference on Digital libraries, 2007 When browsing a digital library of research papers, it is natural to ask which authors are most influential in a particular topic. We present a probabilistic model that ranks authors based on their influence in particular areas of scientific research.
David M. Mimno, Andrew McCallum
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Research on three-dimensional mine roadway system based on WebGL
Gong-kuang zidonghua, 2017 Architecture of three-dimensional mine roadway system based on WebGL was introduced, basic problems of data source processing, roadway topology network construction and roadway model construction were studied, and data preprocessing and cleaning, rule ...
LI Yun +3 more
doaj +1 more source
Digital Mining Technology-Based Teaching Mode for Mining Engineering
International Journal of Emerging Technologies in Learning (iJET), 2016 In this paper, the main problem in present mining engineering teaching was analyzed. Based on the analysis, the study of bringing digital mining technology into mining engineering teaching was presented. Furthermore, a new mining engineering teaching mode that includes mining knowledge demonstration, mining expertise building, mining environment ...
Zhongqiang Chen +3 more
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